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  2. Glycine reuptake inhibitor - Wikipedia

    en.wikipedia.org/wiki/Glycine_reuptake_inhibitor

    A glycine reuptake inhibitor (GRI) is a type of drug which inhibits the reuptake of the neurotransmitter glycine by blocking one or more of the glycine transporters (GlyTs). ). Examples of GRIs include bitopertin (RG1678), iclepertin (BI-425809), ORG-24598, ORG-25935, ALX-5407, and sarcosine, which are selective GlyT1 blockers, and ORG-25435 and N-arachidonylglycine, which are selective GlyT2 blo

  3. Glycine - Wikipedia

    en.wikipedia.org/wiki/Glycine

    Glycine (symbol Gly or G; [6] / ˈ ɡ l aɪ s iː n / ⓘ) [7] is an amino acid that has a single hydrogen atom as its side chain. It is the simplest stable amino acid ( carbamic acid is unstable). Glycine is one of the proteinogenic amino acids .

  4. Hypnotic - Wikipedia

    en.wikipedia.org/wiki/Hypnotic

    Zolpidem tartrate, a common but potent sedative–hypnotic drug.Used for severe insomnia. Hypnotic (from Greek Hypnos, sleep [1]), or soporific drugs, commonly known as sleeping pills, are a class of (and umbrella term for) psychoactive drugs whose primary function is to induce sleep [2] (or surgical anesthesia [note 1]) and to treat insomnia (sleeplessness).

  5. Delta-sleep-inducing peptide - Wikipedia

    en.wikipedia.org/wiki/Delta-sleep-inducing_peptide

    Delta-sleep-inducing peptide was first discovered in 1974 by the Swiss Schoenenberger-Monnier group who isolated it from the cerebral venous blood of rabbits in an induced state of sleep. It was primarily believed to be involved in sleep regulation due to its apparent ability to induce slow-wave sleep in rabbits, but studies on the subject have ...

  6. N-Phenylacetyl-L-prolylglycine ethyl ester - Wikipedia

    en.wikipedia.org/wiki/N-Phenylacetyl-L...

    N-Phenylacetyl-l-prolylglycine ethyl ester is promoted as a nootropic and is a prodrug of cyclic glycine-proline. [a] [2] Other names include the brand name Noopept (Russian: Ноопепт), developmental code GVS-111, and proposed INN omberacetam. [2] [3] [4] Its synthesis was first reported in 1996. [2] It is orally available.

  7. Thiocolchicoside - Wikipedia

    en.wikipedia.org/wiki/Thiocolchicoside

    Side effects of thiocolchicoside can include nausea, allergy and vasovagal reactions. [15] Liver injury, pancreatitis, seizures, blood cell disorders, severe cutaneous disorders, rhabdomyolysis, and reproductive disorders have all been recorded in the French and European pharmacovigilance databases and in the periodic updates that the companies concerned submit to regulatory agencies.

  8. Iclepertin - Wikipedia

    en.wikipedia.org/wiki/Iclepertin

    BI 425809 is an inhibitor of glycine transporter 1 (Gly-T1) that in phase II improved cognition after 12 weeks in patients with schizophrenia. Doses of 10 mg and 25 mg showed the largest separation from placebo.

  9. Oleamide - Wikipedia

    en.wikipedia.org/wiki/Oleamide

    In terms of its sleep inducing effects, it is speculated that oleamide interacts with multiple neurotransmitter systems. [ 8 ] [ 9 ] Some in-vitro studies show that cis -oleamide is an agonist for the cannabinoid receptor CB-1 with an affinity around 8 micromolar. [ 10 ]