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Tolvaptan, sold under the brand name Samsca among others, is an aquaretic drug that functions as a selective, competitive vasopressin receptor 2 (V 2) antagonist used to treat hyponatremia (low blood sodium levels) associated with congestive heart failure, cirrhosis, and the syndrome of inappropriate antidiuretic hormone (SIADH).
Tolvaptan phosphate is a drug used for the treatment of cardiac edema. It is a prodrug of tolvaptan, [1] [2] formulated as the salt tolvaptan sodium phosphate, for intravenous administration. Tolvaptan phosphate is converted into the active drug tolvaptan in the human body following administration.
Palladio conducted the ELiSA Phase II study with lixivaptan in 31 ADPKD patients. In this study, the proportion of study subjects who showed a urine osmolality response consistent with full vasopressin V 2 receptor inhibition was qualitatively and quantitatively similar to the published effect seen in clinical studies conducted with tolvaptan. [13]
Three employees at a Maryland Cracker Barrel have reportedly been dismissed after staff refused to seat a group of students with special needs on Dec. 3 Superintendent of Charles County Public ...
Extreme weather and a smaller supply of tree has pushed up prices, but this year consumers are getting break.
Ectopic and miscarriage. For those who do manage to conceive, things can still go wrong. After an egg is fertilised, it should implant into the lining of the womb.
Specifically, to count as a legitimate view, a user must intentionally initiate the playback of the video and play at least 30 seconds of the video (or the entire video for shorter videos). Additionally, while replays count as views, there is a limit of 4 or 5 views per IP address during a 24-hour period, after which point, no further views ...
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