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Transglutaminase 2 (TG2) is a ubiquitously expressed (intracellular as well as extracellular) protein, with multiple modes of Post-translational regulation, including an allosteric disulfide bond between Cys-370-Cys-371 that renders the enzyme inactive in the extracellular matrix.
Anti-transglutaminase antibodies (ATA) are autoantibodies against the transglutaminase protein. Detection is considered abnormal, and may indicate one of several conditions . Antibodies serve an important role in the immune system by detecting cells and substances that the rest of the immune system then eliminates.
The core domain belongs to the papain-like protease superfamily (CA clan) and uses a Cys-His-Asp catalytic triad. [2] Protein 4.2, also referred to as band 4.2, is a catalytically inactive member of the human transglutaminase family that has a Cys to Ala substitution at the catalytic triad. [6]
A deficiency is associated with ichthyosis lamellaris. [11] Epidermal transglutaminase is the autoantigen, in humans, of dermatitis herpetiformis.. A study on the mutation of keratinocyte transglutaminase (TGK) came to conclude that those affected with ichthyosis lamellaris, present a substantial deficit in keratinocyte transglutaminase activity. [8]
TGM5 is a transglutaminase enzyme.. TGM5 encodes one member of the multigene transglutaminase family. Transglutaminases (TGs) are involved in protein cross-linking by catalyzing the formation of gamma-glutamyl-lysine isodipeptide bonds between adjacent polypeptides (Candi et al. 2005; Eckert et al. 2005).
The IgG antibody is similar to AGA IgA, but is found at higher levels in patients with the IgA-less phenotype. It is also associated with coeliac disease and non-celiac gluten sensitivity. [5] [6] [7] Anti-gliadin antibodies are frequently found with anti-transglutaminase antibodies.
One small study found that when people ate a minimally processed, low-fat, plant-based diet, they consumed fewer calories than people on a low-carb animal-based plan. Better Digestive Health
21818 Ensembl ENSG00000125780 ENSMUSG00000027401 UniProt Q08188 Q08189 RefSeq (mRNA) NM_003245 NM_009374 RefSeq (protein) NP_003236 NP_033400 Location (UCSC) Chr 20: 2.3 – 2.34 Mb Chr 2: 129.85 – 129.89 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse For the Tetris game, see Tetris: The Grand Master. Protein-glutamine gamma-glutamyltransferase E is an enzyme that in humans is ...
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