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DOTA-TATE can be reacted with the radionuclides gallium-68 (T 1/2 = 68 min), lutetium-177 (T 1/2 = 6.65 d) and copper-64 (T 1/2 = 12.7 h) to form radiopharmaceuticals for positron emission tomography (PET) imaging or radionuclide therapy. 177 Lu DOTA-TATE therapy is a form of peptide receptor radionuclide therapy (PRRT) which targets ...
As well as diagnosis and staging of NETs, 68 Ga DOTA conjugated peptide imaging may be used for planning and dosimetry in preparation for lutetium-177 or yttrium-90 DOTA therapy. [35] [36] In June 2016, Netspot (kit for the preparation of gallium Ga-68 dotatate injection) was approved for medical use in the United States. [37] [38]
Gallium (68 Ga) gozetotide or Gallium (68 Ga) PSMA-11 sold under the brand name Illuccix among others, is a radiopharmaceutical made of 68 Ga conjugated to prostate-specific membrane antigen (PSMA) targeting ligand, Glu-Urea-Lys(Ahx)-HBED-CC, used for imaging prostate cancer by positron emission tomography (PET). [11]
[68 Ga] DOTA-pseudopeptides [68 Ga] DOTA-TATE [68 Ga] PSMA [68 Ga] CXCR4; solid and hematologic cancers; Infectious diseases. 18 F] Fluorodeoxysorbitol (FDS) Further ...
Gallium-68 is only used as a positron emitting tag for a ligand which binds to certain tissues, such as DOTATOC, which is a somatostatin analogue useful for imaging neuroendocrine tumors. Gallium-68 DOTA scans are increasingly replacing octreotide scans (a type of indium-111 scan using octreotide as a somatostatin receptor ligand).
The mobile phase is a solvent able to elute (wash out) gallium-68 (III) (68 Ga 3+) after it has been produced by electron capture decay from the immobilized (absorbed) germanium-68. Currently, such 68 Ga (III) is easily eluted with a few mL of 0.05 M, 0.1 M or 1.0 M hydrochloric acid from generators using metal-free tin dioxide [ 3 ] or ...
Lutetium (177 Lu) oxodotreotide or 177 Lu dotatate, brand name Lutathera, is a chelated complex of a radioisotope of the element lutetium with dotatate, used in peptide receptor radionuclide therapy. Specifically, it is used in the treatment of cancers which express somatostatin receptors . [ 5 ]
Copper (64 Cu) oxodotreotide or Copper Cu 64 dotatate, sold under the brand name Detectnet, is a radioactive diagnostic agent indicated for use with positron emission tomography (PET) for localization of somatostatin receptor positive neuroendocrine tumors (NETs) in adults. [2] Common side effects include nausea, vomiting and flushing. [3]