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The short-term effects of cannabis are caused by many chemical compounds in the cannabis plant, including 113 [clarification needed] different cannabinoids, such as tetrahydrocannabinol, and 120 terpenes, [1] which allow its drug to have various psychological and physiological effects on the human body.
They are, in effect, released from the postsynaptic cell and act on the presynaptic cell, where the target receptors are densely concentrated on axonal terminals in the zones from which conventional neurotransmitters are released. Activation of cannabinoid receptors temporarily reduces the amount of conventional neurotransmitter released.
A neurotransmitter for a possible endocannabinoid system in the brain and peripheral nervous system, anandamide (from 'ananda', Sanskrit for 'bliss'), was first characterized in 1992, [18] [19] [20] followed by discovery of other fatty acid neurotransmitters that behave as endogenous cannabinoids having a low-to-high range of efficacy for ...
Scientists analyzed data on nearly 435,000 patients, ages 18 to -74, to see if there was a link between marijuana use and a higher risk of heart disease, stroke, or a heart attack.
Weed affects your ability to make decisions, control emotions, remember important data, plan, organize and solve problems, a new study found, and that impact may last well past your initial high.
Any use of marijuana could raise the risk of heart attack and stroke, even in people who don’t use cigarettes or don’t have existing heart disease, a new study finds.
3D model of 2-Arachidonoylglycerol, an endocannaboid. The endocannabinoid system (ECS) is a biological system composed of endocannabinoids, which are neurotransmitters that bind to cannabinoid receptors, and cannabinoid receptor proteins that are expressed throughout the central nervous system (including the brain) and peripheral nervous system.
The CB1 receptor is a pre-synaptic heteroreceptor that modulates neurotransmitter release when activated in a dose-dependent, stereoselective and pertussis toxin-sensitive manner. [19] The CB1 receptor is activated by cannabinoids , generated naturally inside the body ( endocannabinoids ) or exogenously, normally through cannabis or a related ...