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TOL-463 is an anti-infective medication which is under development for the treatment of bacterial vaginosis (BV) and vulvovaginal candidiasis (VVC) (vaginal yeast infection). [ 3 ] [ 1 ] [ 4 ] [ 2 ] It is a boric acid -based vaginal anti-infective enhanced with ethylenediaminetetraacetic acid (EDTA) which was designed to have improved activity ...
“While boric acid vaginal suppositories are now available in pharmacies or online, this treatment should not be started before seeing a healthcare provider and is usually not recommended outside ...
There are a number of reasons for treatment failure. For example, if the infection is a different kind, such as bacterial vaginosis (the most common cause of abnormal vaginal discharge), rather than thrush. [12] Vaginal boric acid has evidence of effectiveness against non-C. albicans species. [28] [29]
Boric acid is a weak acid, with pK a (the pH at which buffering is strongest because the free acid and borate ion are in equal concentrations) of 9.24 in pure water at 25 °C. But apparent p K a is substantially lower in swimming pool or ocean waters because of interactions with various other molecules in solution.
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One study found that vaginal irrigations with hydrogen peroxide (3%) resulted in a slight improvement, but this was much less than with the use of oral metronidazole. [72] Intravaginal boric acid, alone or in conjunction with other medications, may be helpful in the treatment of recurrent BV. [70] [73] [10]
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Amphotericin B vaginal suppositories are used as an effective form of treatment in combination with boric acid capsules as they are not absorbed into the bloodstream. A first-line treatment for vaginal infections may be the use of terconazole 7-day cream. Several courses may be needed. The cure-rate for this treatment is approximately 40%.
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