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  2. Oxidosqualene cyclase - Wikipedia

    en.wikipedia.org/wiki/Oxidosqualene_cyclase

    Research is being done for other compounds which block different steps in the biosynthesis of cholesterol, including the reaction performed by oxidosqualene cyclase which cyclizes squalene to form lanosterol. [7] Oxidosqualene cyclase, which is downstream of squalene in the pathway, is an attractive target for inhibition.

  3. Lanosterol synthase - Wikipedia

    en.wikipedia.org/wiki/Lanosterol_synthase

    Lanosterol synthase (EC 5.4.99.7) is an oxidosqualene cyclase (OSC) enzyme that converts -2,3-oxidosqualene to a protosterol cation and finally to lanosterol. [5] Lanosterol is a key four-ringed intermediate in cholesterol biosynthesis.

  4. Lanosterol - Wikipedia

    en.wikipedia.org/wiki/Lanosterol

    Lanosterol is a tetracyclic triterpenoid and is the compound from which all animal and fungal steroids are derived. By contrast, plant steroids are produced via cycloartenol . [ 1 ] In the eyes of vertebrates, lanosterol is a natural constituent, having a role in maintaining health of the lens .

  5. 2,3-Oxidosqualene - Wikipedia

    en.wikipedia.org/wiki/2,3-Oxidosqualene

    It is formed when squalene is oxidized by the enzyme squalene monooxygenase. 2,3-Oxidosqualene is the substrate of various oxidosqualene cyclases, including lanosterol synthase, which produces lanosterol, a precursor to cholesterol. [1] The stereoisomer (R)-2,3-oxidosqualene is an inhibitor of lanosterol synthase.

  6. Squalene - Wikipedia

    en.wikipedia.org/wiki/Squalene

    Squalene is an organic compound.It is a triterpene with the formula C 30 H 50.It is a colourless oil, although impure samples appear yellow. It was originally obtained from shark liver oil (hence its name, as Squalus is a genus of sharks).

  7. “We can detect the clear rhythm of autism with just about 1 centimeter of hair,” Arora previously told NBC News, comparing the dynamic to the way a tree’s rings can tell the story of what ...

  8. Squalene monooxygenase - Wikipedia

    en.wikipedia.org/wiki/Squalene_monooxygenase

    Squalene monooxygenase (also called squalene epoxidase) is a eukaryotic enzyme that uses NADPH and diatomic oxygen to oxidize squalene to 2,3-oxidosqualene (squalene epoxide). Squalene epoxidase catalyzes the first oxygenation step in sterol biosynthesis and is thought to be one of the rate-limiting enzymes in this pathway. [ 5 ]

  9. Triterpene - Wikipedia

    en.wikipedia.org/wiki/Triterpene

    Steroids feature a cucurbitane core, although in practice they are biosynthesised from either lanosterol (animals and fungi) or cycloartenol (plants) via the cyclization of squalene. Steroids have two principal biological functions, being either key components of cell membranes or signaling molecules that activate steroid hormone receptors.

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