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  2. Plasma cell dyscrasias - Wikipedia

    en.wikipedia.org/wiki/Plasma_cell_dyscrasias

    In plasma cell leukemia, however, circulating plasma cells reach far higher numbers and at these circulating levels are associated with exceptionally poor survival rates. The International Myeloma Working Group has defined the diagnostic criteria for plasma cell leukemia as the presence in blood of >2x10 9 plasma cells per liter or ...

  3. Plasma cell leukemia - Wikipedia

    en.wikipedia.org/wiki/Plasma_cell_leukemia

    Secondary PCL (sPCL) is diagnosed in 1-4% of patients known to have had multiple myeloma for a median time of ~21 months. It is the terminal phase of these patients' myeloma disease. sPCL patients typically are highly symptomatic due to extensive disease with malignant plasma cell infiltrations in, and failures of, not only the bone marrow but also other organs.

  4. Multiple myeloma - Wikipedia

    en.wikipedia.org/wiki/Multiple_myeloma

    Multiple myeloma (MM), also known as plasma cell myeloma and simply myeloma, is a cancer of plasma cells, a type of white blood cell that normally produces antibodies. [6] Often, no symptoms are noticed initially. [10] As it progresses, bone pain, anemia, renal insufficiency, and infections may occur. [10]

  5. Plasmacytoma - Wikipedia

    en.wikipedia.org/wiki/Plasmacytoma

    Plasmacytoma is a plasma cell dyscrasia in which a plasma cell tumour grows within soft tissue or within the axial skeleton. The International Myeloma Working Group lists three types: solitary plasmacytoma of bone (SPB); extramedullary plasmacytoma (EP), and multiple plasmacytomas that are either primary or recurrent. [1]

  6. Smouldering myeloma - Wikipedia

    en.wikipedia.org/wiki/Smouldering_myeloma

    Smouldering myeloma is a disease classified as intermediate in a spectrum of step-wise progressive diseases termed plasma cell dyscrasias.In this spectrum of diseases, a clone of plasma cells secreting monoclonal paraprotein (also termed myeloma protein or M protein) causes the relatively benign disease of monoclonal gammopathy of undetermined significance.

  7. The myeloid cell line normally produces granulocytes, erythrocytes, thrombocytes, macrophages and mast cells; the lymphoid cell line produces B, T, NK and plasma cells. Lymphomas, lymphocytic leukemias, and myeloma are from the lymphoid line, while acute and chronic myelogenous leukemia, myelodysplastic syndromes and myeloproliferative diseases ...

  8. Monoclonal gammopathy of undetermined significance - Wikipedia

    en.wikipedia.org/wiki/Monoclonal_gammopathy_of...

    MGUS resembles multiple myeloma and similar diseases, but the levels of antibodies are lower, [2] the number of plasma cells (white blood cells that secrete antibodies) in the bone marrow is lower, and it rarely has symptoms or major problems. However, since MGUS can lead to multiple myeloma, which develops at the rate of about 1.5% a year, or ...

  9. Plasma cell - Wikipedia

    en.wikipedia.org/wiki/Plasma_cell

    Plasmacytoma, multiple myeloma, Waldenström macroglobulinemia, heavy chain disease, and plasma cell leukemia are cancers of the plasma cells. [33] Multiple myeloma is frequently identified because malignant plasma cells continue producing an antibody, which can be detected as a paraprotein.

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