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Alzheimer's disease (AD) is a neurodegenerative disease that usually starts slowly and progressively worsens, [2] and is the cause of 60–70% of cases of dementia. [2][15] The most common early symptom is difficulty in remembering recent events. [1] As the disease advances, symptoms can include problems with language, disorientation (including ...
It is an uncommon form of Alzheimer's, accounting for only 5–10% of all Alzheimer's cases. About 60% have a positive family history of Alzheimer's and 13% of them are inherited in an autosomal dominant manner. Most cases of early-onset Alzheimer's share the same traits as the "late-onset" form and are not caused by known genetic mutations.
Amyloid beta. Amyloid beta (Aβ or Abeta) denotes peptides of 36–43 amino acids that are the main component of the amyloid plaques found in the brains of people with Alzheimer's disease. [2] The peptides derive from the amyloid-beta precursor protein (APP), which is cleaved by beta secretase and gamma secretase to yield Aβ in a cholesterol ...
Using machine learning technology, researchers compared the cells, genes and DNA of the Alzheimer’s brain samples to maps of the normal brain generated by the Allen Institute. "With these tools ...
Alzheimer’s usually is a disease of people over age 65 and while simply getting older is the main risk, the APOE gene has long been known to play some role. It comes in three main varieties.
The biochemistry of Alzheimer's disease, the most common cause of dementia, is not yet very well understood. Alzheimer's disease (AD) has been identified as a proteopathy: a protein misfolding disease due to the accumulation of abnormally folded amyloid beta (Aβ) protein in the brain. [1] Amyloid beta is a short peptide that is an abnormal ...
The mutation is extremely rare – it has only ever been found in two Swedish families and has never been found in the general population in any other countries. The mutation had important consequences for Alzheimer's disease research. The mutation occurs in the gene which encodes amyloid precursor protein (APP), which is proteolysed into beta ...
When someone tests positive for the gene that indicates risk for a certain type of cancer, we monitor carefully. ... Prevention trials and improved predictive biomarkers for Alzheimer’s disease ...
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