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Repetitive nerve stimulation is a variant of the nerve conduction study where electrical stimulation is delivered to a motor nerve repeatedly several times per second. By observing the change in the muscle electrical response (CMAP) after several stimulations, a physician can assess for the presence of a neuromuscular junction disease, and differentiate between presynaptic and postsynaptic ...
Axon terminals (also called terminal boutons, synaptic boutons, end-feet, or presynaptic terminals) are distal terminations of the branches of an axon. An axon, also called a nerve fiber, is a long, slender projection of a nerve cell that conducts electrical impulses called action potentials away from the neuron's cell body to transmit those ...
Basic ways that neurons can interact with each other when converting input to output. Summation, which includes both spatial summation and temporal summation, is the process that determines whether or not an action potential will be generated by the combined effects of excitatory and inhibitory signals, both from multiple simultaneous inputs (spatial summation), and from repeated inputs ...
Here is a summary of the sequence of events that take place in synaptic transmission from a presynaptic neuron to a postsynaptic cell. Each step is explained in more detail below. Note that with the exception of the final step, the entire process may run only a few hundred microseconds, in the fastest synapses. [14]
This depolarizing current reaches the presynaptic terminal, and the membrane depolarization that it causes there initiates the opening of voltage-gated calcium channels present on the presynaptic membrane. There is high concentration of calcium in the synaptic cleft between the two participating neurons (presynaptic and postsynaptic). This ...
When the presynaptic terminal is electrically stimulated, an array of molecules embedded in the membrane are activated, and cause the contents of the vesicles to be released into the narrow space between the presynaptic and postsynaptic membranes, called the synaptic cleft.
This difference across the membrane is what the neuron uses to actually do the work of sending messages from the axon hillock of the neuron all the way down to the presynaptic terminal and then on to the postsynaptic terminal because of the release of neurotransmitter into the synaptic cleft. [3]
In the neuromuscular system, nerves from the central nervous system and the peripheral nervous system are linked and work together with muscles. [3] Synaptic transmission at the neuromuscular junction begins when an action potential reaches the presynaptic terminal of a motor neuron , which activates voltage-gated calcium channels to allow ...