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Acquired asplenia occurs for several reasons: . Following splenectomy due to splenic rupture from trauma or because of tumor; After splenectomy with the goal of interfering with splenic function, as a treatment for diseases (e.g. idiopathic thrombocytopenic purpura, thalassemia, spherocytosis), in which the spleen's usual activity exacerbates the disease
The spleen houses antibody-producing lymphocytes in its white pulp and monocytes which remove antibody-coated bacteria and antibody-coated blood cells by way of blood and lymph node circulation. These monocytes, upon moving to injured tissue (such as the heart after myocardial infarction ), turn into dendritic cells and macrophages while ...
Post-splenectomy: A major function of the spleen is the clearance of opsonized, deformed, and damaged erythrocytes by splenic macrophages. If splenic macrophage function is abnormal or absent because of splenectomy, altered erythrocytes will not be removed from the circulation efficiently. Therefore, increased numbers of target cells may be ...
One of the spleen's main tasks is to filter the blood and remove and recycle damaged or old red blood cells. [6] Splenic function can be measured by filtering capabilities, as indicated by number of Howell-Jolly bodies or pitted erythrocytes in the blood. [2] Both of these tests examine whether or not the spleen is functioning normally by ...
Splenocytes are white blood cells that reside in the spleen and are involved in functions of the spleen, such as filtering blood and the immune response. [1] Splenocytes consist of a variety of cell populations such as T and B lymphocytes, dendritic cells and macrophages, which have different immune functions. [2]
It is composed of red pulp which filters the blood, removing foreign material, damaged and worn out red blood cells. It also functions as a storage site for iron, red blood cells and platelets. The rest (~25%) of the spleen is known as the white pulp and functions like a large lymph node being the largest secondary lymphoid organ in the body. [3]
Physicians specialized in hematology are known as hematologists or haematologists. [2] Their routine work mainly includes the care and treatment of patients with hematological diseases, although some may also work at the hematology laboratory viewing blood films and bone marrow slides under the microscope, interpreting various hematological test results and blood clotting test results.
A photomicrograph of the blood showing thrombocytopenia: Specialty: Hematology: Causes: Bone marrow not making enough platelets, body destroying platelets, spleen holding too many platelets [1] Diagnostic method: Complete blood count [1] Treatment: None, immunosuppressants, platelet transfusion, surgical removal of the spleen [1]
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