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Acarbose is an oligosaccharide, whereas miglitol resembles a monosaccharide. Miglitol is fairly well absorbed by the body, as opposed to acarbose. Moreover, acarbose inhibits pancreatic alpha-amylase in addition to alpha-glucosidase, and is degraded by gut bacterial maltogenic alpha-amylase and cyclomaltodextrinase. [4] [5]
Acarbose degradation is the unique feature of glycoside hydrolases in gut microbiota, acarbose degrading glucosidase, which hydrolyze acarbose into an acarviosine-glucose and glucose. [17] Human enzymes do transform acarbose: the pancreatic alpha-amylase is able to perform a rearrangement reaction , moving the glucose unit in the "tail" maltose ...
Miglitol is an oral alpha-glucosidase inhibitor used in the treatment of type 2 diabetes. It works by reversibly inhibiting alpha-glucosidase enzymes in the small intestine, which delays the digestion of complex carbohydrates and subsequently reduces postprandial glucose levels. [ 1 ]
Absorption is strongly correlated with openness to experience. [6] Studies using factor analysis have suggested that the fantasy, aesthetics, and feelings facets of the NEO PI-R Openness to Experience scale are closely related to absorption and predict hypnotisability, whereas the remaining three facet scales of ideas, actions, and values are largely unrelated to these constructs. [5]
A new study found replacing one type of carbs with another and cutting down on animal-based proteins and fats may help reduce weight gain in healthy adults. These are the type of low-carb foods ...
miglitol; acarbose; voglibose; These medications are rarely used in the United States because of the severity of their side-effects (flatulence and bloating). They are more commonly prescribed in Europe. They do have the potential to cause weight loss by lowering the amount of sugar metabolized.
Side effects include weight gain and hypoglycemia.While the potential for hypoglycemia is less than for those on sulfonylureas, [citation needed] it is still a serious potential side effect that can be life-threatening.
Clinical studies are often very specific, typically beginning with animal testing and ending with human testing. In the human testing phase, there is often a group of subjects: one group is given a placebo, and the other is administered a carefully measured therapeutic dose of the drug in question.