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While the mechanisms by which a formulation affects bioavailability and bioequivalence have been extensively studied in drugs, formulation factors that influence bioavailability and bioequivalence in nutritional supplements are largely unknown. [21]
As the contact time between the contaminant and soil increases, a decrease in bioavailability is observed, termed “ageing”, due to diffusion and sorption processes with mineral and organic fractions of soil. [5] Environmental conditions influence bioavailability. Drought conditions result in lower soil water content. This can reduce the ...
The principal effect on BV in everyday life is the organism's current diet, although many other factors such as age, health, weight, sex, etc. all have an effect. In short any condition which can affect the organism's metabolism will vary the BV of a protein source.
Formulation studies then consider such factors as particle size, polymorphism, pH, and solubility, as all of these can influence bioavailability and hence the activity of a drug. The drug must be combined with inactive ingredients by a method that ensures that the quantity of drug present is consistent in each dosage unit e.g. each tablet.
Temperature may affect metabolic transformation, and bioenergetics. An example of this is the movement of the organism may change as well as rates of excretion. [15] If a contaminant is ionic, the change in pH that is influenced by a change in temperature may also influence the bioavailability [1]
Bioavailability is, therefore, a mathematical factor for each individual drug that influences the administered dose. It is possible to calculate the amount of a drug in the blood plasma that has a real potential to bring about its effect using the formula:
Research published in the journal Heart and Circulatory Physiology shows that drinking a small amount of alcohol can positively affect your cardiovascular health. However, this effect reverses as ...
Drug permeability, together with drug aqueous solubility are the two parameters that define the fate of the active ingredient after oral administration and ultimately define its bioavailability. [1] When drug permeability is empirically measured in vitro , it is generally called apparent permeability (P app ) as its absolute value varies ...