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Unlike pharmacological treatments which are administered locally or systemically as a series of interventions, gene therapy aims to establish sustained therapeutic effect after a single, local injection. [1] The main risk factors for osteoarthritis are age [2] [3] and body mass index, [4] [3] as such, OA is predominantly considered a disease of ...
Osteoarthritis typically affects the weight-bearing joints, such as the back, knee and hip. Unlike rheumatoid arthritis, osteoarthritis is most commonly a disease of the elderly. The strongest predictor of osteoarthritis is increased age, likely due to the declining ability of chondrocytes to maintain the structural integrity of cartilage. [69]
In osteoarthritis, there is a loss of articular hyaluronic acid activity, likely contributing to pain and stiffness associated with the condition. Hyaluronic acid injections are an FDA-approved treatment for osteoarthritis of the knee, and are sometimes also used for other joints. However, the merits of HA injections are still disputed.
Osteotomy may be useful in people with knee osteoarthritis, but has not been well studied and it is unclear whether it is more effective than non-surgical treatments or other types of surgery. [144] [145] Arthroscopic surgery is largely not recommended, as it does not improve outcomes in knee osteoarthritis, [146] [147] and may result in harm ...
You can come up with a personalized treatment plan from there. However, the Mayo Clinic also suggests these strategies for managing chronic pain: Practice breathing exercises.
Although surgery has a role in repairing traumatic injuries and broken bones, arthroscopic surgeries do not provide significant or lasting improvements to either pain or function to people with knee pain, and therefore should almost never be performed. [27] Knee pain is pain caused by wear and tear, such as osteoarthritis or a meniscal tear.
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