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Lymphoblastoid cell line, the outcome of lymphocyte infection by Epstein–Barr virus Light Center Length, the distance between the center of the filament (or arc tube) and a reference plane - usually the bottom of the lamp base
Lymphoblast. A lymphoblast is a modified naive lymphocyte with altered cell morphology. It occurs when the lymphocyte is activated by an antigen and increased in volume by nucleus and cytoplasm growth as well as new mRNA and protein synthesis.
When EBV infects B cells in vitro, lymphoblastoid cell lines eventually emerge that are capable of indefinite growth. The growth transformation of these cell lines is the consequence of viral protein expression. [44] EBNA-2, EBNA-3C, and LMP-1, are essential for transformation, whereas EBNA-LP and the EBERs are not. [45]
Acute lymphoblastic leukemia (ALL) is a cancer of the lymphoid line of blood cells characterized by the development of large numbers of immature lymphocytes. [1] Symptoms may include feeling tired, pale skin color, fever, easy bleeding or bruising, enlarged lymph nodes, or bone pain. [1]
Lymphoblastoid cell lines established from blood samples of humans who were centenarians (100 years old or older) have significantly higher PARP activity than cell lines from younger (20 to 70 years old) individuals, [13] again indicating a linkage between longevity and repair capability.
Raji cell culture. Raji is the first continuous human cell line of hematopoietic origin. [1] The Raji cell line is widely used as a transfection host. [2]Raji cells were derived from the B-lymphocytes of an 11-year-old Nigerian Burkitt lymphoma male patient in 1963 by R.J.V. Pulvertaft and was further worked on by B.O. Osunkoya (University College Hospital, Ibadan, Nigeria).
Those cells' differentiation (that is, lymphopoiesis) is not complete until they migrate to lymphatic organs such as the spleen and thymus for programming by antigen challenge. Thus, among leukocytes , the term myeloid is associated with the innate immune system , in contrast to lymphoid , which is associated with the adaptive immune system .
T-cell acute lymphoblastic leukemia (T-ALL) is a type of acute lymphoblastic leukemia characterized by an aggressive malignant neoplasm of the bone marrow. [6] Acute lymphoblastic leukemia (ALL) is a condition, wherein immature white blood cells accumulate in the bone marrow and crowd out normal white blood cells. [7]