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Ever since, mRNA-based therapy has been Karikó's primary research interest. However, in the 1990s, mRNA fell out of favor as many researchers, biotechs, and pharmaceutical companies doubted its potential. Though supported by Elliot Barnathan (who left UPenn in 1997) and David Langer (who then hired her), Karikó found it difficult to gain funding.
The mRNA vaccines made by Pfizer-BioNTech and Moderna were both designed within weeks of the release of the SARS-CoV-2 coronavirus genome, and first to come off manufacturing lines for worldwide use.
Prior to studying medicine, Robert Malone studied computer science at Santa Barbara City College for two years, acting as a teaching assistant in 1981. [2] [8] He received his BS in biochemistry from the University of California, Davis in 1984, his MS in biology from the University of California, San Diego in 1988, and his MD from Northwestern University Feinberg School of Medicine in 1991.
Rosbash's research group cloned the Drosophila period gene in 1984 and proposed the Transcription Translation Negative Feedback Loop [2] for circadian clocks in 1990. In 1998, they discovered the cycle gene, clock gene, and cryptochrome photoreceptor in Drosophila through the use of forward genetics , by first identifying the phenotype of a ...
Two pioneering scientists who created the technology behind life-saving Covid-19 vaccines have won the Nobel Prize in medicine or physiology.
Drew Weissman (born September 7, 1959) is an American physician and immunologist known for his contributions to RNA biology. Weissman is the inaugural Roberts Family Professor in Vaccine Research, director of the Penn Institute for RNA Innovation, and professor of medicine at the Perelman School of Medicine at the University of Pennsylvania (Penn).
In 2007, Moore moved her research group to the Biochemistry and Molecular Pharmacology Department at the University of Massachusetts Chan Medical School (UMass Med). [ 9 ] [ 10 ] In 2011, Moore was the recipient of the American Society for Biochemistry and Molecular Biology 's William C. Rose Award [ 11 ] for excellence in mentoring.
Physician-scientist Margaret Liu stated that the efficacy of the new COVID-19 mRNA vaccines could be due to the "sheer volume of resources" that went into development, or that the vaccines might be "triggering a nonspecific inflammatory response to the mRNA that could be heightening its specific immune response, given that the modified ...