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The gene for LAMP2 has 9 coding exons and 2 alternate last exons, 9a and 9b. [6] When the last exon is spliced with the alternative exon, it is a variant called LAMP2b, which varies in the last 11 amino acids of its C-terminal sequence: in the luminal domain, the transmembrane domain, and the cytoplasmic tail.
Illustration of a eukaryotic cell membrane Comparison of a eukaryotic vs. a prokaryotic cell membrane. The cell membrane (also known as the plasma membrane or cytoplasmic membrane, and historically referred to as the plasmalemma) is a biological membrane that separates and protects the interior of a cell from the outside environment (the extracellular space).
Ferroportin-1, also known as solute carrier family 40 member 1 (SLC40A1) or iron-regulated transporter 1 (IREG1), is a protein that in humans is encoded by the SLC40A1 gene. [5] Ferroportin is a transmembrane protein that transports iron from the inside of a cell to the outside of the cell.
Stromal interaction molecule 1 is a protein that in humans is encoded by the STIM1 gene. [5] [6] [7] STIM1 has a single transmembrane domain, and is localized to the endoplasmic reticulum, and to a lesser extent to the plasma membrane. [8] Even though the protein has been identified earlier, its function was unknown until recently.
This is important for the regulation of cell size, e.g., during cell growth. The substances within the vesicle are released into the exterior. These might be waste products or toxins, or signaling molecules like hormones or neurotransmitters during synaptic transmission. Proteins embedded in the vesicle membrane are now part of the plasma membrane.
Alternatively, iron can enter the cell directly via plasma membrane divalent cation importers such as DMT1 and ZIP14 (Zrt-Irt-like protein 14). [22] Again, iron enters the cytoplasm in the ferrous state after being reduced in the extracellular space by a reductase such as STEAP2, STEAP3 (in red blood cells), Dcytb (in enterocytes) and SDR2. [21]
The movement of phospholipids, even those located in the outer leaflet of the membrane, is regulated by the actin-based membrane skeleton meshwork.Which is surprising, because the membrane skeleton is located on the cytoplasmic surface of the plasma membrane, and cannot directly interact with the phospholipids located in the outer leaflet of the plasma membrane.
These closed membranes are double membrane-bond, with lysosomes inside it. The main function of these membrane is degradation, as role in cellular homeostasis. However, the origin of them has remained unclear. Maybe it is the plasma membrane, the endoplasmic reticulum (ER) and the mitochondria. But the ER- mitochondria contact site have markers ...