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One of the most prevalent forms of adverse drug reactions is cutaneous reactions, [1] with drug-induced urticaria ranking as the second most common type, preceded by drug-induced exanthems. [2] Urticaria, commonly known as hives , manifests as weals, itching, burning, redness, swelling, and angioedema —a rapid swelling of lower skin layers ...
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Cefixime, sold under the brand name Suprax among others, is an antibiotic medication used to treat a number of bacterial infections. [5] These infections include otitis media , strep throat , pneumonia , urinary tract infections , gonorrhea , and Lyme disease . [ 5 ]
Chronic spontaneous urticaria, despite its cause being unknown, is linked to a higher prevalence of autoimmune diseases, and is often worsened by triggers like stress, infections, certain foods, or nonsteroidal anti-inflammatory drugs. The hives and angioedema seen in CSU is thought to be linked to the degranulation of skin mast cells.
Urticaria is a vascular reaction of the skin characterized by the appearance of wheals. Angioedema , which can occur alone or with urticaria, is characterized by a well-defined, edematous swelling that involves subcutaneous tissues, abdominal organs, and/or upper airway.
Several theories have been put forth, however the pathophysiology of pressure urticaria is unknown. [3] Although there isn't an obvious early cutaneous reaction, the time of the reaction following the application of pressure to the skin, the shape of the lesions, and the infiltrating cells observed on histopathologic examination are indicative of a late-phase reaction. [5]
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Delayed pressure urticaria is known as one of the more painful subsets of physical urticaria due to formed hives being deep-seated and appearing after 4–6 hours. [ 1 ] Causes