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Centralized web application that provides data format transformations and facilitates connections with other bioinformatics tools Web browser: LGPL: Broad Institute, collaborative project GENtle: An equivalent to the proprietary Vector NTI, a tool to analyze and edit DNA sequence files Linux, macOS, Windows: GPL: Magnus Manske: gget
VectorBee; PeptiCloud; BlueTractorSoftware DNADynamo; Agilent Technologies RFLP Decoder Software, Fish Species; Applied Biosystems GeneMapper; Joint BioEnergy Institute j5; CLC bio CLC DNA Workbench Software
DNADynamo is a general purpose DNA and Protein sequence analysis package that can carry out most of the functions required by a standard research molecular biology laboratory DNA and Protein Sequence viewing, editing and annotating; Contig assembly and chromatogram editing including comparison to a reference sequence to identify mutations
Multiple Expectation maximizations for Motif Elicitation (MEME) is a tool for discovering motifs in a group of related DNA or protein sequences. [1] MEME takes as input a group of DNA or protein sequences and outputs as many motifs as requested up to a user-specified statistical confidence threshold. MEME uses statistical modeling techniques to ...
It has since been adopted for use as a tool in the genetic engineering of higher organisms. Designing an appropriate gRNA is an important element of genome editing with the CRISPR/Cas system. A gRNA can and at times does have unintended interactions ("off-targets") with other locations of the genome of interest.
Cytidine base editor is a novel therapy in which the cytidine (C) changes to thymidine (T). Adenine base editor (ABE), [214] in this there is a change in base complements from adenine (A) to Guanine (G). The mutations were directly installed in cellular DNA so that the donor template is not required. The base editings can only edit point mutations.
These tools use different mechanisms to bind a predetermined sequence of DNA (“target”), which they cleave (or "cut"), creating a double-stranded chromosomal break (DSB) that summons the cell's DNA repair mechanisms (non-homologous end joining and homologous recombination ) and leads to site-specific modifications. [2]
Genome editing, or genome engineering, or gene editing, is a type of genetic engineering in which DNA is inserted, deleted, modified or replaced in the genome of a living organism. Unlike early genetic engineering techniques that randomly inserts genetic material into a host genome, genome editing targets the insertions to site-specific locations.