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This exceedingly high uniformity means that fewer individuals are required to produce results with the same level of statistical significance when an inbred line is used in comparison to an outbred line in the same experiment. [6] Breeding of inbred strains is often towards specific phenotypes of interest such as behavioural traits like alcohol ...
The origins and history of recombinant inbred strains are described by Crow. [1] While the potential utility of recombinant inbred strains in mapping analysis of complex polygenic traits was obvious from the outset, the small number of strains only made it feasible to map quantitative traits with very large effects (quasi-Mendelian loci).
Inbreeding is a technique used in selective breeding. For example, in livestock breeding, breeders may use inbreeding when trying to establish a new and desirable trait in the stock and for producing distinct families within a breed, but will need to watch for undesirable characteristics in offspring, which can then be eliminated through ...
Each parental line was crossed to the B73 maize inbred (chosen as a reference line due to its use in the public maize sequencing project and wide deployment as one of the most successful commercial inbred lines) to create the F1 population. The F1 plants were then self-fertilized for six generations in order to create a total of 200 homozygous ...
In plants, the term inbred backcross line (IBL) refers to a line (i.e. population) of plants derived from the repeated backcrossing of a line with artificially recombinant DNA with the wild type, operating some kind of selection that can be phenotypical or through a molecular marker (for the production of an introgression line).
Breeding from too small a gene pool, especially direct inbreeding, can lead to the passing on of undesirable characteristics or even a collapse of a breed population due to inbreeding depression. Therefore, there is a question, and often heated controversy, as to when or if a breed may need to allow "outside" stock in for the purpose of ...
Coisogenic strains may also occur through a spontaneous mutation that occurs in an inbred strain. [3] To create a coisogenic strain through breeding, a mouse with the specific mutation on a locus is mated to an inbred strain (e.g., C57BL/6J) mouse. The offspring of the mutated mouse with the inbred strain has a 50% chance of carrying the ...
Line breeding is differentiated from inbreeding by excluding pairings between parents and offspring, and between full siblings. Outcrossing is the planned breeding between two unrelated dogs, used to increase genetic diversity in a breed and decrease genetic issues or abnormalities inherited from line breeding or inbreeding.