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Once the chemotherapy is completed, the stored stem cells are infused back into the patient's body. This procedure helps to restore the bone marrow and support the recovery of blood cells. ASCT has allowed for the administration of HDC, with improvements in supportive care reducing associated morbidity and mortality. [1] [2]
High-dose chemotherapy using the CMVP combination was found to be able to be given safely to younger patients with high-risk breast cancer. The high-dose chemotherapy resulted in a significantly low relapse rate, and high-dose chemotherapy was associated with significantly longer disease-free and overall survival in this patient population.
Consolidation chemotherapy is given after remission in order to prolong the overall disease-free time and improve overall survival. The drug that is administered is the same as the drug that achieved remission. [6]: 55–59
Opdivo plus chemotherapy demonstrated a statistically significant and clinically meaningful benefit for the primary and secondary endpoints of overall survival (OS) in patients whose tumors ...
The overall survival, or OS rates, in the TROPION-Lung01 trial "did not reach statistical significance", the company said in a presentation at the World Conference on Lung Cancer in San Diego.
In males, researchers suggest that the overall reduction in cancer death rates is due in large part to a reduction in tobacco use over the last half century, estimating that the reduction in lung cancer caused by tobacco smoking accounts for about 40% of the overall reduction in cancer death rates in men and is responsible for preventing at least 146,000 lung cancer deaths in men during the ...
With a minimum follow-up of 21.0 months, Opdivo with chemotherapy reduced the risk of disease recurrence, progression, or death by 37% across randomized patients when administer
A 2024 systematic review of the literature found that chemoradiation with 5-FU and mitomycin C, as used in the Nigro Protocol, improves outcomes like colostomy-free survival in anal cancer patients compared to alternatives like cisplatin. However, it can lead to more severe side effects, especially blood-related toxicity. [7]