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Once the chemotherapy is completed, the stored stem cells are infused back into the patient's body. This procedure helps to restore the bone marrow and support the recovery of blood cells. ASCT has allowed for the administration of HDC, with improvements in supportive care reducing associated morbidity and mortality. [1] [2]
High-dose chemotherapy using the CMVP combination was found to be able to be given safely to younger patients with high-risk breast cancer. The high-dose chemotherapy resulted in a significantly low relapse rate, and high-dose chemotherapy was associated with significantly longer disease-free and overall survival in this patient population.
Consolidation chemotherapy is given after remission in order to prolong the overall disease-free time and improve overall survival. The drug that is administered is the same as the drug that achieved remission. [6]: 55–59
In males, researchers suggest that the overall reduction in cancer death rates is due in large part to a reduction in tobacco use over the last half century, estimating that the reduction in lung cancer caused by tobacco smoking accounts for about 40% of the overall reduction in cancer death rates in men and is responsible for preventing at least 146,000 lung cancer deaths in men during the ...
Long-term effects were also a concern, as patients were often cured and could expect long survival after chemotherapy. Infertility was a major long-term side effect, and even more seriously, the risk of developing treatment-related myelodysplasia or acute leukemia was increased up to 14-fold in patients who received MOPP. [ 14 ]
Median overall survival (OS) was 30.0 months with pembrolizumab and 14.2 months with chemotherapy, hazard ratio 0.63, p = 0.002. [52] Pembrolizumab was associated with significantly fewer adverse events than was platinum-based chemotherapy.
Among colorectal cancer patients with peritoneal carcinomatosis cytoreductive surgery, with the addition of HIPEC can be used to prolong overall survival in patients. [5] In a typical case an incision is made from the sternum down to the pelvis, and cancerous cells are removed. Then heated chemotherapy liquid is poured in to destroy remaining ...
In a series of 322 patients undergoing bland embolization for HCC with a median follow-up of 20 months, 1-, 2-, and 3- year overall survival rates were 66%, 46% and 33% respectively. When patients with extra-hepatic disease or portal vein involvement were excluded, overall 1-, 2- and 3-year survival rates rose to 84%, 66% and 51%, and median ...
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