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Long-term use has been associated with kidney failure, and rarely liver failure, and it can exacerbate the condition of patients with heart failure. [8] At low doses, it does not appear to increase the risk of heart attack; however, at higher doses it may. [10] Ibuprofen can also worsen asthma. [10]
The term usually refers to damage induced by excessive use of combinations of these medications, especially combinations that include phenacetin. It may also be used to describe kidney injury from any single analgesic medication. The specific kidney injuries induced by analgesics are renal papillary necrosis and chronic interstitial nephritis.
It's unclear if it is safe in among people who have had a heart attack, stroke or irregular heartbeat within the last six months, and you should talk to your doctor if you have abnormal blood ...
Kidney failure is especially a risk if the patient is also concomitantly taking an ACE inhibitor (which removes angiotensin II's vasoconstriction of the efferent arteriole) and a diuretic (which drops plasma volume, and thereby RPF)—the so-called "triple whammy" effect. [82] In rarer instances NSAIDs may also cause more severe kidney ...
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Nephrotoxicity is toxicity in the kidneys. It is a poisonous effect of some substances, both toxic chemicals and medications, on kidney function. [1] There are various forms, [2] and some drugs may affect kidney function in more than one way. Nephrotoxins are substances displaying nephrotoxicity.
About 12.2 million new strokes are diagnosed each year. One in four stroke survivors will experience another stroke. Stroke survivors are at an increased risk of developing major heart issues ...
[122] [126] High doses or levels of AAS, including testosterone, can cause polycythemia—high red blood cell and/or hemoglobin levels that increase the risk of stroke—as an adverse effect. [ 121 ] [ 122 ] Conversely, whether via castration, NSAA monotherapy, or CAB , decreased erythropoiesis resulting in mild anemia is a common side effect ...