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Tiagabine, a drug used as an anticonvulsant, acts by inhibiting the GABA transporter 1. Neurotransmitter transporters inhibitors Vesicular transporters could provide an alternative therapeutic target for the modulation of chemical neurotransmission, as the activity of these transporters could affect the quantity of neurotransmitter released.
Betaine transporter (BGT1; SLC6A12) Creatinine transporter 1 (CT1; SLC6A8) Taurine transporter (TauT; SLC6A6) GAT1 and GAT3 are the major GABA transporters in the brain and spinal cord, expressed by both neurons and some astrocytes. [4] GAT2 and BGT1 are also expressed in the brain, but at low levels and mostly in the meninges.
The exception to this is the 5-HT 3 receptor which is a ligand-gated ion channel. In 2014, a novel 5-HT receptor was isolated from the small white butterfly, Pieris rapae , and named pr5-HT 8 . It does not occur in mammals and shares relatively low similarity to the known 5-HT receptor classes.
The serotonin transporter (SERT or 5-HTT) also known as the sodium-dependent serotonin transporter and solute carrier family 6 member 4 is a protein that in humans is encoded by the SLC6A4 gene. [5] SERT is a type of monoamine transporter protein that transports the neurotransmitter serotonin from the synaptic cleft back to the presynaptic ...
Cotransmission allows for more complex effects at postsynaptic receptors, and thus allows for more complex communication to occur between neurons. In modern neuroscience, neurons are often classified by their cotransmitter. For example, striatal "GABAergic neurons" utilize opioid peptides or substance P as their primary cotransmitter.
The dopamine transporter (DAT, also sodium-dependent dopamine transporter) is a membrane-spanning protein coded for in humans by the SLC6A3 gene (also known as DAT1), that pumps the neurotransmitter dopamine out of the synaptic cleft back into cytosol. In the cytosol, other transporters sequester the dopamine into vesicles for storage and later ...
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The family of glutamate transporters is composed of two primary subclasses: the excitatory amino acid transporter (EAAT) family and vesicular glutamate transporter (VGLUT) family. In the brain, EAATs remove glutamate from the synaptic cleft and extrasynaptic sites via glutamate reuptake into glial cells and neurons , while VGLUTs move glutamate ...