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145 912.34 g·mol −1. Aducanumab, sold under the brand name Aduhelm, is a monoclonal antibody designed to treat Alzheimer's disease. [2][3] It is a monoclonal antibody [3][2] that targets aggregated forms (plaque) [4][5] of amyloid beta (Aβ) found in the brains of people with Alzheimer's disease to reduce its buildup. [6][7] It was developed ...
Treatment with the cancer drug restored function in the hippocampus in an Alzheimer’s mouse model. It has long been understood that glucose metabolism in the brain is disrupted by aging and ...
BioViva was founded in 2015. [2] The CEO, Liz Parrish, started the company by becoming the first person in human history to take gene therapies associated with lengthening lifespans in model organism, [3] she appeared at WIRED Health 2017 in London to discuss BioViva's testing of gene therapies targeting hallmarks of the ageing process.
Gene therapy is a medical technology that aims to produce a therapeutic effect through the manipulation of gene expression or through altering the biological properties of living cells. [ 1 ][ 2 ][ 3 ] The first attempt at modifying human DNA was performed in 1980, by Martin Cline, but the first successful nuclear gene transfer in humans ...
AOH1996 is an experimental anticancer medication which acts as a small molecule inhibitor of proliferating cell nuclear antigen (PCNA) and is in Phase I clinical trials at City of Hope as of August 2023 for the treatment of solid tumors. [1][2][3][4] AOH1996 was created to target a post-translationally modified isoform of PCNA, termed caPCNA ...
October 3, 2024 at 7:00 AM. Researchers have hailed a promising breakthrough in the development of drugs to treat Alzheimer’s disease. For the first time, scientists have created a drug that ...
Amyloid beta. Amyloid beta (Aβ or Abeta) denotes peptides of 36–43 amino acids that are the main component of the amyloid plaques found in the brains of people with Alzheimer's disease. [ 2 ] The peptides derive from the amyloid-beta precursor protein (APP), which is cleaved by beta secretase and gamma secretase to yield Aβ in a cholesterol ...
Imatinib, sold under the brand names Gleevec and Glivec (both marketed worldwide by Novartis) among others, is an oral targeted therapy medication used to treat cancer. [2] Imatinib is a small molecule inhibitor targeting multiple tyrosine kinases such as CSF1R , ABL , c-KIT , FLT3 , and PDGFR-β .