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Codeine/paracetamol, also called codeine/acetaminophen and co-codamol, is a compound analgesic, comprising codeine phosphate and paracetamol (acetaminophen). Codeine/paracetamol is used for the relief of mild to moderate pain when paracetamol or non-steroidal anti-inflammatory drugs (NSAIDs; such as ibuprofen, aspirin, and naproxen) alone do not sufficiently relieve symptoms.
Lean or purple drank (known by numerous local and street names) is a polysubstance drink used as a recreational drug.It is prepared by mixing prescription-grade cough or cold syrup containing an opioid drug and an anti-histamine drug with a soft drink and sometimes hard candy.
Codeine is marketed as both a single-ingredient drug and in combination preparations with paracetamol (as co-codamol: e.g., brands Paracod, Panadeine, and the Tylenol-with-codeine series, including Tylenol 3 and 1, 2, and 4); with aspirin (as co-codaprin); or with ibuprofen (as Nurofen Plus).
Cough medicines, especially those containing dextromethorphan and codeine, are often abused as recreational drugs. [30] [31] Abuse may result in hallucinations, loss of consciousness and death. Many cough syrups can contain acetaminophen which will cause liver damage in recreational users. [31]
Flucloxacillin, also known as floxacillin, is an antibiotic used to treat skin infections, external ear infections, infections of leg ulcers, diabetic foot infections, and infection of bone. [6] It may be used together with other medications to treat pneumonia , and endocarditis . [ 6 ]
Figures released by the Office for National Statistics (ONS), and cited by the MHRA, revealed deaths involving codeine more than doubled in a decade, jumping from 88 in 2011 to 200 in 2021.
A number of factors can potentially increase the risk of developing paracetamol toxicity. Chronic excessive alcohol consumption can induce CYP2E1, thus increasing the potential toxicity of paracetamol. In one study of patients with liver injury, 64% reported alcohol intakes of greater than 80 grams a day, while 35% took 60 grams a day or less. [28]
If you feel drunk, take a break from drinking. The effects of alcohol can build up over time, then hit you suddenly. If you feel drunk, take a break and switch to a non-alcoholic drink for the ...