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Ototoxicity results in cochlear and/or vestibular dysfunction which can manifest as sensorineural hearing loss, tinnitus, hyperacusis, dizziness, vertigo, or imbalance. [6] [7] Presentation of symptoms vary in singularity, onset, severity and reversibility. [6]
Signs and symptoms of ototoxicity include tinnitus, hearing loss, dizziness and nausea and/or vomiting. [3] The diagnosis of medicine-induced ototoxicity is challenging as it usually shows only mild symptoms in early stages. Thus, prospective ototoxicity monitoring would be required when patients are using ototoxic medications. [1]
Since the inner ear is not directly accessible to instruments, identification is by patient report of the symptoms and audiometric testing. Of those who present to their doctor with sensorineural hearing loss, 90% report having diminished hearing, 57% report having a plugged feeling in ear, and 49% report having ringing in ear ().
The symptoms mentioned above are the external signs of the physiological response to cochlear overstimulation. Here are some elements of this response: Damaged sensory hairs (stereocilia) of the hair cells; damaged hair cells degenerate and die. In humans and other mammals, dead hair-cells are never replaced; the resulting hearing loss is ...
The symptoms of cochlear hydrops fluctuate, and the condition may stabilize or go away on its own after several years. However, because the organ of Corti undergoes stress during the hydrops episodes, long-term hearing loss, tinnitus, or hyperacusis is possible. It is considered by some that cochlear hydrops is an early form of Meniere's disease.
Hearing impaired children in Japan's coastal city of Shizuoka will from next year be able to listen, learn and speak better thanks to an A$6.5 million ($4.4 million) programme funded by the city ...
Combinations of vestibular and cochlear symptoms were present in a significant minority of cases, and additional skin and neurological symptoms were also present in a significant minority of cases. In the majority of cases a large right to left shunt was detected, and associated with right sided lateralisation of inner ear symptoms. [13]
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