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Anthrax is a disease caused by Bacillus anthracis, a spore-forming, Gram positive, rod-shaped bacterium (Fig. 1).The lethality of the disease is caused by the bacterium's two principal virulence factors: (i) the polyglutamic acid capsule, which is anti-phagocytic, and (ii) the tripartite protein toxin, called anthrax toxin.
Skin lesion from anthrax Anthrax skin lesion on the neck Anthrax skin lesion on the face. Cutaneous anthrax, also known as hide-porter's disease, is when anthrax occurs on the skin. It is the most common (>90% of cases) and least dangerous form (low mortality with treatment, 23.7% mortality without).
Heinrich Hermann Robert Koch (/ k ɒ x / KOKH; [1] [2] German: [ˈʁoːbɛʁt ˈkɔx] ⓘ; 11 December 1843 – 27 May 1910) was a German physician and microbiologist.As the discoverer of the specific causative agents of deadly infectious diseases including tuberculosis, cholera and anthrax, he is regarded as one of the main founders of modern bacteriology.
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Bacillus anthracis is a gram-positive and rod-shaped bacterium that causes anthrax, a deadly disease to livestock and, occasionally, to humans. It is the only permanent pathogen within the genus Bacillus. Its infection is a type of zoonosis, as it is transmitted from animals to humans. [1]
He was able to identify the causative organism, but was unaware of its true etiology. [5] [6] Later on, German microbiologist Robert Koch investigated the etiology of Bacillus anthracis, and discovered its ability to produce "resting spores" that could stay alive in the soil for a long period of time to serve as a future source of infection. [7]
Nonetheless, Koch was already aware that the causative agent of cholera, Vibrio cholerae, could be found in both sick and healthy people, invalidating his first postulate. [ 6 ] [ 9 ] Since the 1950s, Koch's postulates have been treated as obsolete for epidemiology research, but they are still taught to emphasize historical approaches to ...
Leitenberg and Zilinskas with Kuhn quote a Russian source which indicates that "According to the official data, 95 people were infected, 68 (71.5 per cent) died [but] actually the number of the dead and infected was larger". [6] The leakage of anthrax hit the ceramics factory, south of Compound 19, the hardest.