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Sodium phosphates are popular in commerce in part because they are inexpensive and because they are nontoxic at normal levels of consumption. [4] However, oral sodium phosphates when taken at high doses for bowel preparation for colonoscopy may in some individuals carry a risk of kidney injury under the form of phosphate nephropathy.
Phosphate nephropathy or nephrocalcinosis [1] is an adverse renal condition that arises with a formation of phosphate crystals within the kidney's tubules. This renal insufficiency is associated with the use of oral sodium phosphate (OSP) such as C.B. Fleet's Phospho soda and Salix's Visocol, for bowel cleansing prior to a colonoscopy.
High phosphate levels can be avoided with phosphate binders and dietary restriction of phosphate. [5] If the kidneys are operating normally, a saline diuresis can be induced to renally eliminate the excess phosphate. In extreme cases, the blood can be filtered in a process called hemodialysis, removing the excess phosphate. [5]
ECF has a sodium concentration of approximately 140 mEq/L. [27] Because cell membranes are permeable to water but not sodium, the movement of water across membranes affects the concentration of sodium in the blood. Sodium acts as a force that pulls water across membranes, and water moves from places with lower sodium concentration to places ...
Sodium tripolyphosphate was an excellent builder used in laundry detergent powders. [21] However, due to issues of biodegradability many countries have banned the use of phosphates in detergents. Manufacturers are using substitutes such as EDTA and other biodegradable chemicals instead.
Sodium hexametaphosphate (SHMP) is a salt of composition Na 6 [(PO 3) 6]. [3] Sodium hexametaphosphate of commerce is typically a mixture of metaphosphates (empirical formula: NaPO 3), of which the hexamer is one, and is usually the compound referred to by this name. Such a mixture is more correctly termed sodium polymetaphosphate.
Disodium phosphate (DSP), or disodium hydrogen phosphate, or sodium phosphate dibasic, is an inorganic compound with the chemical formula Na 2 H P O 4. It is one of several sodium phosphates . The salt is known in anhydrous form as well as hydrates Na 2 HPO 4 · n H 2 O , where n is 2, 7, 8, and 12.
High sodium consumption (5 g or more of salt per day) and insufficient potassium intake (less than 3.5 grams (0.12 oz) per day) have been linked to high blood pressure and increased risk of heart disease, stroke, and kidney disease. [6] [7] As an essential nutrient, sodium is involved in numerous cellular and organ functions. Several national ...