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Poisoning can occur if pyrethroid containing flea treatment products, which are intended for dogs, are used on cats. The livers of cats detoxify pyrethroids via glucuronidation more poorly than dogs, which is the cause of this difference. [15] Aside from cats, pyrethroids are typically not toxic to mammals or birds. [16]
At normal application rates, allethrin is slightly toxic to bees. [4] Insects subject to exposure become paralyzed (nervous system effect) before dying. Allethrins are toxic to cats [5] because they either do not produce, or produce less of certain isoforms of glucuronosyltransferase, which serve in hepatic detoxifying metabolism pathways. [6]
Pyrethrins and Pyrethroids Fact Sheet - National Pesticide Information Center; Pyrethrins and pyrethroids on the EXTOXNET; Pyrethrin and Permethrin Toxicity in Dogs and Cats; Wagner, S. L. (2000). "Fatal asthma in a child after use of an animal shampoo containing pyrethrin". The Western Journal of Medicine. 173 (2): 86– 7. doi:10.1136/ewjm ...
If you’re unsure whether your cat needs a medical evaluation, try calling the ASPCA Animal Poison Control Center (888-426-4435) or the Pet Poison Hotline (855-764-7661).
Permethrin is toxic to cats; however, it has little effect on dogs. [4] [49] [50] Many cats die after being given flea treatments intended for dogs, or by contact with dogs having recently been treated with permethrin. [51] In cats it may induce hyperexcitability, tremors, seizures, and death. [52]
Cypermethrin is very toxic to cats which cannot tolerate the therapeutic doses for dogs. [6] This is associated with UGT1A6 deficiency in cats, the enzyme responsible for metabolizing cypermethrin. As a consequence, cypermethrin remains much longer in the cat's organs than in dogs or other mammals and can be fatal in large doses.
Etofenprox is a pyrethroid derivative which is used as an insecticide. [1] Mitsui Chemicals Agro Inc. is the main manufacturer of the chemical. It is also used as an ingredient in flea medication for cats and dogs.
The World Health Organization published in 2004 that "Prallethrin is of low mammalian toxicity, with no evidence of carcinogenicity" and "is very toxic to bees and fish but of low toxicity to birds." [2] Prallethrin is a member of the pyrethroid class of insecticides. Pyrethroids have historically been classified into two groups, Type I and ...