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In November 2016 the FDA accepted Flexion's New Drug Application for FX006, an extended-release formulation of triamcinolone acetonide (a corticosteroid), branded "Zilretta". [5] In October 2017 Zilretta was approved by the FDA as the first and only extended-release intra-articular therapy for patients confronting osteoarthritis-related knee ...
Gene therapy for osteoarthritis is also being investigated as technology to create a drug that would act as a disease-modifying drug. Several approved drugs are being investigated as repurposed agents in the treatment of osteoarthritis such as liraglutide (anti-diabetic and anti-obesity drug: NCT02905864), Metformin (anti-diabetic drug ...
In osteoarthritis, there is a loss of articular hyaluronic acid activity, likely contributing to pain and stiffness associated with the condition. Hyaluronic acid injections are an FDA-approved treatment for osteoarthritis of the knee, and are sometimes also used for other joints. However, the merits of HA injections are still disputed.
Medications like Ozempic and Wegovy, which are used to treat type 2 diabetes and boost weight loss, may also help reduce knee osteoarthritis-related pain in people with obesity, a trial finds.
Two FDA advisory committees will begin meeting Wednesday on a Pfizer drug called tanezumab that could bring relief for osteoarthritis pain.
In clinical studies, NGF inhibitors have demonstrated efficacy in reducing pain and improving function in persons with knee or hip osteoarthritis. [2] While injectable NGF inhibitors (anti-NGF antibodies) have demonstrated greater efficacy in pain relief compared to NSAID and opioid medications, [3] those receiving the treatment were more likely to experience rapid progression of the disease ...
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