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Chemically, benzoylecgonine is the benzoate ester of ecgonine. It is a primary metabolite of cocaine, [1] and is pharmacologically inactive. [2] It is the corresponding carboxylic acid of cocaine, its methyl ester. It is formed in the liver by the metabolism of cocaine by hydrolysis, catalysed by carboxylesterases, and subsequently excreted in ...
2 to 3 days in blood, up to 2 weeks in blood of heavy users [12] However, it depends on whether actual THC or THC metabolites are being tested for, the latter having a much longer detection time than the former. THC (found in marijuana) may only be detectable in saliva/oral fluid for 2 to 24 hours in most cases, though in rare cases has been ...
It is structurally similar to cocaine, which is the methyl ester of benzoylecgonine. Cocaethylene is formed by the liver when cocaine and ethanol coexist in the blood. [ 1 ] In 1885, cocaethylene was first synthesized (according to edition 13 of the Merck Index ), [ 2 ] and in 1979, cocaethylene's side effects were discovered.
Cocaine increases alertness, feelings of well-being, euphoria, energy, sociability, and sexuality. The former are some of the desired effects of cocaine intoxication. Not having the normal use of mental faculties by reason of the introduction of cocaine is defined drug intoxication by the laws in America, Europe, and most of the rest of the World, and it is a serious crime in specific contexts ...
Benzoylecgonine (197e) is the inactive primary metabolite of cocaine generated through hydrolysis of the C2 methyl ester. In vitro binding studies indicate that benzoylecgonine is ~2,200x less potent than cocaine at the dopamine transporter, possibly due to zwitterion formation preventing strong DAT binding.
At the time of the crash, Lopes' blood alcohol content was .20, the DA's office said, which is more than twice the legal limit for driving of .08. His next court appearance is scheduled for May 22.
According to the official autopsy report obtained by Us Weekly on Wednesday, May 15, Brown had a blood ethanol rate of .307%. The legal limit is 0.08% for adults over the age of 21. While a ...
A toxicology screening ordered as part of the month-long investigation indicated Chao, 50, had a blood alcohol concentration of 0.233. The legal limit to drive in Texas is 0.08.