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Daunorubicin should only be administered in a rapid intravenous infusion. It should not be administered intramuscularly or subcutaneously , since it may cause extensive tissue necrosis . It should also never be administered intrathecally (into the spinal canal ), as this will cause extensive damage to the nervous system and may lead to death .
[4] [6] It contains the liposomal bound daunorubicin, an anthracycline topoisomerase inhibitor, and cytarabine, a nucleoside metabolic inhibitor. [ 4 ] Medical uses
Anthracyclines remain some of the most widely used chemotherapeutic agents but their potential is limited by its dose-limiting toxicities. Currently, there are many studies being conducted in the search for anthracyclines with better anti-tumour efficacy or with reduced side effects using different nanotechnology-based drug delivery systems.
Liposomal daunorubicin is intravenously administered. It utilizes the liposomal carrier system that provides a favorable pharmacokinetic profile at the site of KS lesions resulting in a 10-fold increase in concentrations compared to that which is achieved with conventional preparations.
Uses and indications Normal cells are more able than cancer cells to repair damage from chemotherapy drugs. ... 50 mg/m 2: 65 mg/m 2: 70 mg/m 2: 70 mg/m 2: 70 mg/m 2 ...
"In the 60s, the skin tends to become drier, thinner and more delicate due to decreased natural oil production and a decline in collagen and elastin," said Dr. Hannah Kopelman, host of the podcast ...
A new study has shown a spike in marijuana use among seniors in the last decade — specifically elderly women and those who are married. Marijuana use spikes among women over 65, study say [Video ...
Epirubicin is favoured over doxorubicin, the most popular anthracycline, in some chemotherapy regimens as it appears to cause fewer side-effects. Epirubicin has a different spatial orientation of the hydroxyl group at the 4' carbon of the sugar - it has the opposite chirality - which may account for its faster elimination and reduced toxicity.
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