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Insulin degludec is an ultra-long acting insulin that, unlike insulin glargine, is active at a physiologic pH.The addition of hexadecanedioic acid via an amide linkage to lysine at the B29 position allows for the formation of multi-hexamers in subcutaneous tissues. [16]
In two late-stage trials, they compared blood sugar management over the course of a year with weekly injections of insulin efsitora alfa or daily injections of insulin degludec.
Insulin degludec/insulin aspart is indicated for the treatment of diabetes mellitus in adults, adolescents and children from the age of two years. [6] Insulin degludec and insulin aspart are slightly different from human insulin. [6] The differences mean that insulin degludec is absorbed more slowly by the body. [6]
Insulin degludec/liraglutide, sold under the brand name Xultophy, is a fixed-dose combination medication for the treatment of adults with type 2 diabetes to improve glycemic control in combination with diet and exercise. [7] [8] It contains insulin degludec and liraglutide. [7] [8] It is administered by subcutaneous injection. [7] [8]
An analysis of Phase 3 clinical trials found that once-weekly insulin icodec was better at reducing high blood glucose levels in comparison with the once-daily therapy insulin degludec, but ...
At the 26-week mark of this 78-week trial, researchers reported that participants using efsitora had an average reduction of 0.86% in their A1C levels compared to 0.75% for the insulin degludec ...
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