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Atipamezole, sold under the brand name Antisedan among others, is a synthetic α 2 adrenergic receptor antagonist used for the reversal of the sedative and analgesic effects of dexmedetomidine and medetomidine in dogs. Its reversal effect works by competing with the sedative for α 2-adrenergic receptors and displacing them.
However, the neurotoxic side effects occurring at the required dosages have prevented the widespread use of metronidazole as an adjuvant agent in radiation therapy. [32] However, other nitroimidazoles derived from metronidazole such as nimorazole with reduced electron affinity showed less serious neuronal side effects and have found their way ...
However, researchers recently carried out a study looking at the effects of an age-reversal pill on dogs, and – while it might sound like something from a sci-fi movie – their findings give us ...
Side effects in dogs and cats include hypersalivation, diarrhea, loss of appetite, and vomiting. [12] [16] Eight percent of dogs taking maropitant at doses meant to prevent motion sickness vomited right after, likely due to the local effects maropitant had on the gastrointestinal tract. Small amounts of food beforehand can prevent such post ...
Common side effect is darkening of the tongue and teeth. [58] It also causes darkening of faeces which may confuse with the signs of gastrointestinal bleeding. [ 59 ] In renal failure patients, long-term use of bismuth may cause toxicity, resulting in encephalopathy ( ataxia , headache, confusion , seizures).
These effects are known from the drug's components as well as from other antibiotics. A very rare but dangerous reaction is Stevens–Johnson syndrome, a life-threatening condition affecting the skin, which has also been described under metronidazole and tetracycline as separate drugs. [3]
Drugs which cause disulfiram-like reactions upon ingestion of alcohol as an unintended effect include: [6] [1] [7] Abacavir Cephalosporins , but only these with a methylthiotetrazole side chain or a methylthiodioxotriazine ring; thought to be due to common N -methylthiotetrazole metabolite , which is similar in structure to disulfiram. [ 8 ]
In dogs, sheep, horses, and cattle, the half-life is very short: only 1.21– 5.97 minutes. Complete elimination of the drug can take up to 23 minutes in sheep and up to 49 minutes in horses. [1] [3] In young rats the half-life is one hour. [18] Xylazine has a large volume of distribution of V d = 1.9 – 2.5 for horses, cattle, sheep, and dogs ...