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Cefazolin, also known as cefazoline and cephazolin, is a first-generation cephalosporin antibiotic used for the treatment of a number of bacterial infections. [2] Specifically it is used to treat cellulitis , urinary tract infections , pneumonia , endocarditis , joint infection , and biliary tract infections . [ 2 ]
The contraindication, however, should be viewed in the light of recent epidemiological work suggesting, for many second-generation (or later) cephalosporins, the cross-reactivity rate with penicillin is much lower, having no significantly increased risk of reactivity over the first generation based on the studies examined.
Specifically, a small amount of evidence supports the use of intravenous cefazolin once rather than three times a day when it is combined with probenecid. [ 2 ] It has also found use as a masking agent , [ 3 ] potentially helping athletes using performance-enhancing substances to avoid detection by drug tests.
Based on previous studies, though, the risk of endocarditis following cutaneous surgery is low and thus the use of antibiotic prophylaxis is controversial. Although this practice is appropriate for high-risk patients when skin is contaminated, it is not recommended for noneroded, noninfected skin. [8]
Prophylactic surgery (also known as preventive surgery or risk-reducing surgery) is a form of surgery most commonly intended to minimize or eliminate the risk of the patient developing cancer in an organ or gland before development occurs. This can be a life-saving procedure for those at high risk of developing cancer in certain organs.
Methods to decrease surgical site infections in spine surgery include the application of antiseptic skin preparation (a.g. Chlorhexidine gluconate in alcohol which is twice as effective as any other antiseptic for reducing the risk of infection [9]), judicious use of surgical drains, prophylactic antibiotics, and vancomycin. [10]
Their use in surgical procedures is to help prevent infection of incisions. They have an important role in dental antibiotic prophylaxis where their use may prevent bacteremia and consequent infective endocarditis. Antibiotics are also used to prevent infection in cases of neutropenia particularly cancer-related. [37] [38]
When the risk of anaerobic infection is high, as with intra-abdominal and post-surgical infections, proper antimicrobial prophylaxis may reduce the risk 90% of the time, other organisms were mixed in with the anaerobic gram-positive cocci and microaerophilic streptococci. This includes Streptococcus species, and Staphylococcus aureus.