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Nephrotoxicity (kidney damage) is the primary dose-limiting side effect and is of major clinical concern. Cisplatin selectively accumulates into the proximal tubule via basolateral-to-apical transport, where it disrupts mitochondrial energetics and endoplasmic reticulum Ca 2+ homeostasis and stimulates reactive oxygen species and pro ...
Kidney damage (nephrotoxicity) in the form of proximal tubular injury is the main reason to stop cisplatin. [16] Other side effects of cisplatin include nausea and vomiting which usually necessitate premedication with antiemetic medications before infusion; ear damage (ototoxicity), which could manifest in varying levels of hearing loss ...
A chemo-protective agent [1] is any drug that helps to reduce the side- effects of chemotherapy.These agents protect specific body parts from harmful anti-cancer treatments that could potentially cause permanent damage to important bodily tissues.
The liver damage can consist of damage to liver cells, hepatic sinusoidal syndrome (obstruction of the veins in the liver), cholestasis (where bile does not flow from the liver to the intestine) and liver fibrosis. [127] [128] Nephrotoxicity (kidney damage) can be caused by tumor lysis syndrome and also due direct effects of drug clearance by ...
These medications may also cause renal failure or certain kidney lesions, like those in the glomeruli or tubules. [32] Certain chemotherapy medications might cause hepatotoxic side effects in addition to renal toxicity, which calls for a thorough evaluation of liver function before starting treatment and possible dose adjustments. [33]
There are various forms, [2] and some drugs may affect kidney function in more than one way. Nephrotoxins are substances displaying nephrotoxicity. Nephrotoxicity should not be confused with some medications predominantly excreted by the kidneys needing their dose adjusted for the decreased kidney function (e.g., heparin, lithium).
Kidney disease. CDC. 10 Signs You May Have Kidney Disease. National Kidney Foundation. Aging and kidney disease. National Kidney Foundation. Kidney Transplant Outcomes in Recipients Over the Age ...
Cisplatin was the first to be developed. [9] Cisplatin is particularly effective against testicular cancer; the cure rate was improved from 10% to 85%. [10] Similarly, the addition of cisplatin to adjuvant chemotherapy led to a marked increase in disease-free survival rates for patients with medulloblastoma - again, up to around 85%.