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Enquiry into the evolution of ageing, or aging, aims to explain why a detrimental process such as ageing would evolve, and why there is so much variability in the lifespans of organisms. The classical theories of evolution (mutation accumulation, antagonistic pleiotropy, and disposable soma) [1][2][3] suggest that environmental factors, such as ...
The network theory of aging supports the idea that multiple connected processes contribute to the biology of aging. Kirkwood and Kowald helped to establish the first model of this kind by connecting theories and predicting specific mechanisms. In departure of investigating a single mechanistic cause or single molecules that lead to senescence ...
Society portal. v. t. e. Gerontology (/ ˌdʒɛrənˈtɒlədʒi / JERR-ən-TOL-ə-jee) is the study of the social, cultural, psychological, cognitive, and biological aspects of aging. The word was coined by Ilya Ilyich Mechnikov in 1903, from the Greek γέρων (gérōn), meaning "old man", and -λογία (-logía), meaning "study of". [ 1 ...
Biogerontology is the sub-field of gerontology concerned with the biological aging process, its evolutionary origins, and potential means to intervene in the process. The term "biogerontology" was coined by S. Rattan, and came in regular use with the start of the journal Biogerontology in 2000. It involves interdisciplinary research on the ...
The mitochondrial theory of ageing has two varieties: free radical and non-free radical. The first is one of the variants of the free radical theory of ageing. It was formulated by J. Miquel and colleagues in 1980 [1] and was developed in the works of Linnane and coworkers (1989). [2] The second was proposed by A. N. Lobachev in 1978.
Ageing (or aging in American English) is the process of becoming older. The term refers mainly to humans, many other animals, and fungi, whereas for example, bacteria, perennial plants and some simple animals are potentially biologically immortal. [ 1 ] In a broader sense, ageing can refer to single cells within an organism which have ceased ...
The hallmarks of aging are the types of biochemical changes that occur in all organisms that experience biological aging and lead to a progressive loss of physiological integrity, impaired function and, eventually, death. They were first listed in a landmark paper in 2013 [1] to conceptualize the essence of biological aging and its underlying ...
In 1968 it took the form and became known as the neuroendocrine theory of aging. [38] [39] [40] 1956 Denham Harman proposed the free-radical theory of aging and demonstrated that free radical reactions contribute to the degradation of biological systems. [41] The theory is based on the ideas of Rebeca Gerschman and her colleagues put forward in ...