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At 30 mg/day, the QTc increased by 10.7 ms. [39] A QTc increase of less than 60 ms is not likely to confer significant risk. [38] The 30 mg/day escitalopram dose induced significantly less QTc prolongation than a therapeutically equivalent 60 mg/day dose of citalopram, which increased the QTc interval by 18.5 ms. [38]
The reuptake effects of venlafaxine are dose-dependent. At low doses (<150 mg/day), it acts only on serotonergic transmission. At moderate doses (>150 mg/day), it acts on serotonergic and noradrenergic systems, whereas at high doses (>300 mg/day), it also affects dopaminergic neurotransmission. [22]
These side effects are more likely at higher doses (above 0.5–1 mg). [ 13 ] In clinical trials brotizolam 0.125 to 0.5 mg improved sleep in insomniacs similarly to nitrazepam 2.5 and 5 mg, flunitrazepam 2 mg and triazolam 0.25 mg, whilst brotizolam 0.5 mg was shown to be superior to flurazepam 30 mg, but inferior to temazepam 30 mg in some ...
Common side effects include daytime sleepiness, headache, nausea, and diarrhea. [11] More severe side effects include memory problems and hallucinations. [7] While flumazenil, a GABA A –receptor antagonist, can reverse zolpidem's effects, usually supportive care is all that is recommended in overdose. [20]
The XML Metadata Interchange (XMI) is an Object Management Group (OMG) standard for exchanging metadata information via Extensible Markup Language (XML). It can be used for any metadata whose metamodel can be expressed in Meta-Object Facility (MOF) , a platform-independent model (PIM).
Fluvoxamine, sold under the brand name Luvox among others, is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class. [8] It is primarily used to treat major depressive disorder and, perhaps more-especially, obsessive–compulsive disorder (OCD), [9] but is also used to treat anxiety disorders [10] such as panic disorder, social anxiety disorder, and post-traumatic stress ...
Common side effects include loss of appetite, abdominal pain, diarrhea, and feeling tired. [4] Serious side effects include suicidal thoughts, low blood cell levels, and lupus erythematosus. [4] [5] It is unclear if it has adverse effects on the fetus during pregnancy. [4] Ethosuximide is in the succinimide family of medications. Its mechanism ...
Nitrazepam in doses of 5 mg or more causes significant deterioration in vigilance performance combined with increased feelings of sleepiness. [32] Nitrazepam at doses of 5 mg or higher impairs driving skills [33] and like other hypnotic drugs, it is associated with an increased risk of traffic accidents. [34]