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Propylhexedrine, as a nasal decongestant, is currently marketed under the trade name Benzedrex. The name Benzedrex was initially trademarked by Smith, Kline & French in 1944. [70] The brand was passed onto Menley James Laboratories (through a subsidiary, NuMark Laboratories) in 1990, and was finally acquired by B. F. Ascher & Co. in 1998. [71] [72]
Phenylephrine is pregnancy category C. Due to the lack of studies done in animals and in humans, it is not known whether there is harm to the fetus. Phenylephrine should only be given to pregnant women who have a clear need. [51] Extended use may cause rhinitis medicamentosa, a condition of rebound nasal congestion. [52]
[4] [5] Use is not recommended during pregnancy. [2] Xylometazoline is in the decongestant and alpha-adrenergic agonist families of medication. [5] [6] One study classified it with selectivity ratios in alpha 2 adrenergic receptors of 151 for a2A vs a2B, 4.5 a2A vs a2C, and 33.9 a2B vs a2C. Making it a highly selective a2A agonist. [7]
Nasal sprays While people tend to prefer taking a pill to using a nasal spray, the sprays are effective at relieving congestion, said Dr. Vin Gupta, a pulmonologist and an affiliate faculty member ...
Women are taking the over-the-counter decongestant Mucinex, claiming the active ingredient, guaifenesin, helped to increase their fertility — and get pregnant.
In addition to steroid nasal sprays and antihistamine sprays, Tracy says phenylephrine is still considered effective in nasal spray form — though Tracy warns it can be “habit-forming” if ...
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