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Liver transplantation is a treatment option for end-stage liver disease and acute liver failure, although availability of donor organs is a major limitation. Liver transplantation is highly regulated, and only performed at designated transplant medical centers by highly trained transplant physicians.
The first human liver transplant operation was performed by Thomas Starzl in 1963. The next two decades were marked by difficulties with donor organ quality, recipient selection, operative and...
In 1963, Starzl et al. performed the first liver transplantation. In the first five liver transplantations no patient survived more than 23 days. In 1967, stimulated by Calne who used antilymphocytic serum, Starz …
Liver transplantation, first performed in humans 60 years ago, is now the standard of care for patients with life-threatening liver disease. This article focuses on current developments in...
With a very long history of setbacks and successes, organ transplantation is one of the greatest medical achievements of the twentieth century. The idea of transferring body parts from one human to another is described in ancient Roman, Indian, Chinese, and Egyptian mythology.
Liver transplantation (LT) is a lifesaving gift and proven intervention in managing patients with acute and chronic end-stage liver disease. It restores normal health, lifestyle and extends lifespan by 15 years. The advent of liver transplantation came as a safety net to treat various liver diseases when all other medical interventions have failed.
Whole‐liver transplantation from brain‐dead donors began being performed in the 1960s; however, acceptable outcomes were only achieved in the 1980s as a result of the development of novel immunosuppressants and technological progress.
Since 1963, when the first human liver transplantation (LT) was performed by Thomas Starzl, the world has witnessed 50 years of development in surgical techniques, immunosuppression, organ allocation, donor selection, and the indications and contraindications for LT.
The first human liver transplant operation was performed by Thomas Starzl in 1963. The next two decades were marked by difficulties with donor organ quality, recipient selection, operative and perioperative management, immunosuppression and infectious complications.
This chapter will outline the early, hard-won advances in vascular surgery, immunology, organ preservation, and transplantation of the kidney that preceded successful liver transplantation, and will describe the further evolution of liver transplantation in the past three decades.