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A study found that oral spironolactone had "about 10 to 20% of the feminizing effect of cyproterone acetate" on sexual differentiation in male rat fetuses, with a dose of 40 mg/day spironolactone having an effect equal to 1–3 mg/day cyproterone acetate. [35] [36]
100–200: 200: 50: 11–52 d ... levels with 10 versus 20 mg/day cyproterone acetate and testosterone levels for the two groups were combined. ... of spironolactone ...
Cyproterone acetate (CPA), sold alone under the brand name Androcur or with ethinylestradiol under the brand names Diane or Diane-35 among others, is an antiandrogen and progestin medication used in the treatment of androgen-dependent conditions such as acne, excessive body hair growth, early puberty, and prostate cancer, as a component of feminizing hormone therapy for transgender individuals ...
1967: Cyproterone acetate was first studied clinically, to treat sexual deviance in men [225] 1969: Cyproterone acetate was first studied in the treatment of acne, hirsutism, seborrhea, and scalp hair loss in women [226] 1969: The antiandrogenic activity of spironolactone is discovered [227]
The combination of spironolactone with a birth control pill in the treatment of acne appears to have similar effectiveness to a birth control pill alone and the combination of a birth control pill with cyproterone acetate, flutamide, or finasteride. [64] However, this was based on low- to very-low-quality evidence. [64]
[1] [2] Cyproterone and CPA were among the first antiandrogens to be developed. [4] The term cyproterone is often used as a synonym and shorthand for cyproterone acetate, and when the term occurs, what is almost always being referred to is, confusingly, CPA and not actually cyproterone. Cyproterone itself, unlike CPA, was never introduced for ...
5–20 mg every 2 wks Estradiol dipropionate: Agofollin: Estrogen: IM, SC: 2–10 mg/wk or 5–20 mg every 2 wks Estradiol benzoate: Progynon-B: Estrogen: IM, SC: 0.5–1.5 mg every 2–3 days Estriol: Ovestin [c] Estrogen: Oral: 4–6 mg/day Spironolactone: Aldactone: Antiandrogen: Oral: 100–400 mg/day Cyproterone acetate: Androcur ...
Testosterone levels with 100 to 300 mg/day oral cyproterone acetate and low-dose oral estrogen in men. [11] The estrogen used was 0.1 mg/day diethylstilbestrol (DES), [11] which has been described as an "extremely low" dosage. [12] Levels of testosterone were decreased by about 95% with the combination and by about 61% with cyproterone acetate ...