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Genetic recombination and recombinational DNA repair also occurs in bacteria and archaea, which use asexual reproduction. Recombination can be artificially induced in laboratory (in vitro) settings, producing recombinant DNA for purposes including vaccine development. V(D)J recombination in organisms with an adaptive immune system is a type of ...
Genetic recombination can be viewed as fundamentally a DNA repair process, and that when it occurs during meiosis it is an adaptation for repairing the genomic DNA that is passed on to progeny. [ 44 ] [ 45 ] Experimental findings indicate that a substantial benefit of meiosis is recombinational repair of DNA damage in the germline , as ...
Most recombination events appear to be the SDSA type. Conversion of one allele to the other is often due to base mismatch repair during homologous recombination: if one of the four chromatids during meiosis pairs up with another chromatid, as can occur because of sequence homology, DNA strand transfer can occur followed by mismatch repair. This ...
Chromosomal crossover, or crossing over, is the exchange of genetic material during sexual reproduction between two homologous chromosomes' non-sister chromatids that results in recombinant chromosomes. It is one of the final phases of genetic recombination, which occurs in the pachytene stage of prophase I of meiosis during a process called ...
During meiosis non-crossover recombinants also occur frequently and these appear to arise mainly by the SDSA pathway as well. [49] [50] Non-crossover recombination events occurring during meiosis likely reflect instances of repair of DNA double-strand damages or other types of DNA damages.
Meiosis generates genetic variation in the diploid cell, in part by the exchange of genetic information between the pairs of chromosomes after they align (recombination). Thus, on this view, [28] an advantage of meiosis is that it facilitates the generation of genomic diversity among progeny, allowing adaptation to adverse changes in the ...
This is followed by two cell divisions to generate haploid gametes. After the DNA is replicated in meiosis, the homologous chromosomes pair up so that their DNA sequences are aligned with each other. During this period before cell divisions, genetic information is exchanged between homologous chromosomes in genetic recombination. Homologous ...
The grasshopper Melanoplus femurrubrum was exposed to an acute dose of X-rays during each individual stage of meiosis, and chiasma frequency was measured. [7] Irradiation during the leptotene-zygotene stages of meiosis, that is, prior to the pachytene period in which crossover recombination occurs, was found to increase subsequent chiasma ...