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2. Aldosterone synthase - Wikipedia

   en.wikipedia.org/wiki/Aldosterone_synthase

   Aldosterone synthase, also called steroid 18-hydroxylase, corticosterone 18-monooxygenase or P450C18, is a steroid hydroxylase cytochrome P450 enzyme involved in the biosynthesis of the mineralocorticoid aldosterone and other steroids. The enzyme catalyzes sequential hydroxylations of the steroid angular methyl group at C18 after initial 11β ...

3. Glucocorticoid remediable aldosteronism - Wikipedia

   en.wikipedia.org/wiki/Glucocorticoid_remediable...

   The genes encoding aldosterone synthase and 11β-hydroxylase are 95% identical and are close together on chromosome 8. In individuals with GRA, there is unequal crossing over so that the 5' regulatory region of the 11-hydroxylase gene is fused to the coding region of the aldosterone synthase. [citation needed]

4. Apparent mineralocorticoid excess syndrome - Wikipedia

   en.wikipedia.org/wiki/Apparent_mineralocorticoid...

   The inactivating mutation leads to elevated local concentrations of cortisol in the aldosterone sensitive tissues like the kidney. Cortisol at high concentrations can cross-react and activate the mineralocorticoid receptor due to the non-selectivity of the receptor, leading to aldosterone-like effects in the kidney.

5. Steroidogenic enzyme - Wikipedia

   en.wikipedia.org/wiki/Steroidogenic_enzyme

   18-Hydroxylase (aldosterone synthase) – mineralocorticoid synthesis; 21-Hydroxylase – corticosteroid synthesis; Cytochrome P450 (CYP1, 2, 3) – estrogen metabolism; Hydroxysteroid dehydrogenases (and ketosteroid reductases) 3α-Hydroxysteroid dehydrogenase – androgen, progestogen, and neurosteroid synthesis and metabolism

6. Primary aldosteronism - Wikipedia

   en.wikipedia.org/wiki/Primary_aldosteronism

   Measuring aldosterone alone is not considered adequate to diagnose primary hyperaldosteronism. Rather, both renin and aldosterone are measured, and a resultant aldosterone-to-renin ratio (ARR) is used for case detection. [20] [21] A high aldosterone-to-renin ratio suggests the presence of primary hyperaldosteronism. The diagnosis is made by ...

7. Mineralocorticoid receptor - Wikipedia

   en.wikipedia.org/wiki/Mineralocorticoid_receptor

   The mineralocorticoid receptor (or MR, MLR, MCR), also known as the aldosterone receptor or nuclear receptor subfamily 3, group C, member 2, (NR3C2) is a protein that in humans is encoded by the NR3C2 gene that is located on chromosome 4q31.1-31.2. [5] MR is a receptor with equal affinity for mineralocorticoids and glucocorticoids.

8. Zona glomerulosa - Wikipedia

   en.wikipedia.org/wiki/Zona_glomerulosa

   The enzyme aldosterone synthase (also known as CYP11B2) acts in this location [3] [4] The expression of neuron-specific proteins in the zona glomerulosa cells of human adrenocortical tissues has been predicted and reported by several authors [5] [6] [7] and it was suggested that the expression of proteins like the neuronal cell adhesion ...

9. Baxdrostat - Wikipedia

   en.wikipedia.org/wiki/Baxdrostat

   Edit; View history; Tools. Tools. ... Download as PDF; Printable version; In other projects ... It is an aldosterone synthase inhibitor. [2] [3] References