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Its high degree of lipophilicity (fat solubility) allows it to be detected in the urine for up to 18 months. [ 5 ] [ 57 ] Less than 1% of the unchanged drug is excreted via the kidneys in the urine, in which 20–70% is excreted as conjugated or unconjugated metabolites, whereas 5–6% is excreted in feces.
Abbrev. [1]Meaning [1] Latin (or Neo-Latin) origin [1]; a.c. before meals: ante cibum a.d., ad, AD right ear auris dextra a.m., am, AM morning: ante meridiem: nocte ...
Guidelines on the choice of agents and how best to step up treatment for various subgroups in hypertension (high blood pressure) have changed over time and differ between countries. A Comparison of International Guidelines on Goal Blood Pressure and Initial Therapy for Adults With Hypertension (adapted from JNC 8 guidelines [ 1 ] )
p.r.n., PRN pro re nata: as needed PRN is pertactin, a virulence factor of the bacterium that causes pertussis: pt. perstetur: continue pulv. pulvis: powder p.v., PV per vaginam: vaginally q quaque: every, per q.1 h, q.1° quaque 1 hora: every 1 hour (can replace 1 with other numbers) q4PM at 4:00 pm (can replace 4 with other numbers)
Generally abbreviated to "P.R.N." or "PRN", pro re nata refers to the administration of prescribed medication whose timing is left to the patient (in the case of patient-controlled analgesia), nurse, or caregiver, as opposed to medication that is taken according to a fixed (primarily daily) schedule (a.k.a. "scheduled dosage").
Clark's rule is a medical term referring to a mathematical formula used to calculate the proper dosage of medicine for children aged 2–17 based on the weight of the patient and the appropriate adult dose. [1] The formula was named after Cecil Belfield Clarke (1894–1970), a Barbadian physician who practiced throughout the UK, the West Indies ...
Typically, different doses are recommended for children 6 years and under, for children aged 6 to 12 years, and for persons 12 years and older, but outside of those ranges the guidance is slim. [2] This can lead to serial under- or over-dosing, as smaller people take more than they should and larger people take less.
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