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In autoimmune disease, anti-apolipoprotein H (AAHA) antibodies, also called anti-β 2 glycoprotein I antibodies, comprise a subset of anti-cardiolipin antibodies and lupus anticoagulant. These antibodies are involved in sclerosis and are strongly associated with thrombotic forms of lupus. [ 1 ]
Pregnancy-specific beta-1-glycoprotein is a major product of the syncytiotrophoblast in the placenta, reaching concentrations of 100 to 290 mg/L at term in the serum of pregnant women. [ 3 ] [ 12 ] PSGs are synthesized through a gene's coding for a specific protein.
β 2-glycoprotein 1, also known as beta-2 glycoprotein 1 and Apolipoprotein H (Apo-H), is a 38 kDa multifunctional plasma protein that in humans is encoded by the APOH gene. [5] One of its functions is to bind cardiolipin. When bound, the structure of cardiolipin and β 2-GP1 both undergo large changes in structure. [6]
Pregnancy-specific beta-1-glycoprotein 1 encoded by the PSG1 gene. Produced in high quantity during pregnancy. CD68: 110 kDa highly glycosylated transmembrane protein which is mainly located in lysosomes.
Antiphospholipid antibody tests are either liquid-phase coagulation assays to detect lupus anticoagulant or solid phase ELISA (enzyme-linked immunosorbent assay) to detect anti-cardiolipin antibodies and β 2 glycoprotein 1. [24] The use of testing for antibodies specific for individual targets of aPL such as phosphatidylserine is currently ...
Beta-1,3-galactosyl-O-glycosyl-glycoprotein+beta-1,3-N-acetylglucosaminyltransferase at the U.S. National Library of Medicine Medical Subject Headings (MeSH) v t
Hemopexin (or haemopexin; Hpx; Hx), also known as beta-1B-glycoprotein, is a glycoprotein that in humans is encoded by the HPX gene [5] [6] [7] and belongs to the hemopexin family of proteins. [8] Hemopexin is the plasma protein with the highest binding affinity for heme.
Alpha-1-B glycoprotein is a 54.3 kDa protein in humans that is encoded by the A1BG gene. [ 5 ] The protein encoded by this gene is a plasma glycoprotein of unknown function. The protein shows sequence similarity to the variable regions of some immunoglobulin supergene family member proteins.
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