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The QTc interval is longer in females, as well as having a stronger response to IKr-blocking agents. In males, the presence of testosterone upregulates IKr channels and therefore decreases QT interval. [2] Stated otherwise, estrogens prolong the QT interval, while androgens shorten it and decrease the response to IKr-blocking agents. [citation ...
The effect on sodium channels could be of particular relevance for seizure protection. Although topiramate does inhibit high-voltage-activated calcium channels, its relevance to clinical activity is uncertain. Effects on specific GABA-A receptor isoforms could also contribute to the antiseizure activity of the drug.
QT prolongation and phototoxicity. [2] Sulfacarbamide: 1988 Germany Dermatologic, hematologic and hepatic reactions. [3] Sulfamethoxydiazine: 1988 Germany Unknown. [3] Sulfamethoxypyridazine: 1986 UK Dermatologic and hematologic reactions. [3] Suloctidil: 1985 Germany, France, Spain Hepatotoxicity. [3] Suprofen: 1986–1987 UK, Spain, US Kidney ...
In the kidneys, dofetilide is eliminated via cation exchange (secretion). Agents that interfere with the renal cation exchange system, such as verapamil , cimetidine , hydrochlorothiazide , itraconazole , ketoconazole , prochlorperazine , and trimethoprim should not be administered to individuals taking dofetilide.
Long QT syndrome is associated with a prolonged QTc, although in some genetically proven cases of LQTS this prolongation can be hidden, known as concealed LQTS. [23] The QTc is less than 450 ms in 95% of normal males, and less than 460 ms in 95% of normal females. LQTS is suggested if the QTc is longer than these cutoffs.
Nephrotoxicity is toxicity in the kidneys. It is a poisonous effect of some substances, both toxic chemicals and medications, on kidney function. [1] There are various forms, [2] and some drugs may affect kidney function in more than one way. Nephrotoxins are substances displaying nephrotoxicity.
Priapism is a non-intimate prolonged arousal that isn’t relieved by climax. It is a serious medical emergency that can cause pain, lasting damage to the privates and permanent dysfunction if it ...
The cardiac features of JLNS can be diagnosed by measuring the QT interval corrected for heart rate (QTc) on a 12-lead electrocardiogram (ECG). The QTc is less than 450 ms in 95% of normal males, and less than 460 ms in 95% of normal females. In those with Jervell and Lange-Nielsen syndrome the QTc is typically greater than 500 ms. [8]
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