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Methotrexate-induced papular eruption appears in patients being treated with methotrexate, such as those with rheumatic disease, presenting with erythematous indurated papules, usually located on the proximal extremities. [1] It has been suggested that it may represent a cutaneous small-vessel vasculitis. [2]
Treatment: Generally, there is no treatment necessary, as the rash will go away on its own. However, its symptoms can be managed with over-the-counter medication like acetaminophen, per Mount Sinai .
Caplan syndrome presents with cough and shortness of breath in conjunction with features of rheumatoid arthritis, such as painful joints and morning stiffness. Examination should reveal tender, swollen metacarpophalangeal joints and rheumatoid nodules; auscultation of the chest may reveal diffuse crackles that do not disappear on coughing or taking a deep breath.
The standard treatment for dermatomyositis is a corticosteroid drug, given either in pill form or intravenously. Immunosuppressant drugs, such as azathioprine and methotrexate, may reduce inflammation in people who do not respond well to prednisone. Periodic treatment using intravenous immunoglobulin can also improve recovery
Methotrexate was originally developed and continues to be used for chemotherapy, either alone or in combination with other agents.It is effective for the treatment of several cancers, including solid tumours of breast, head and neck, lung, bladder, as well as acute lymphocytic leukemias, non-Hodgkin's lymphoma, osteosarcoma, and choriocarcinoma and other trophoblastic neoplasms.
Heat rash is caused by a blockage of the sweat duct in the skin, said Austin dermatologist Dr. Miriam Hanson, according to Sanova Dermatology. The type of rash depends on whether it’s a ...
Rheumatoid arthritis [2] Possibly collagen and/or citrullinated self proteins Chronic arthritis, inflammation, destruction of articular cartilage and bone Tuberculin reaction (Mantoux test) [3] Tuberculin Induration and erythema around injection site indicates previous exposure
Stevens–Johnson syndrome (SJS) is a type of severe skin reaction. [1] Together with toxic epidermal necrolysis (TEN) and Stevens–Johnson/toxic epidermal necrolysis (SJS/TEN) overlap, they are considered febrile mucocutaneous drug reactions and probably part of the same spectrum of disease, with SJS being less severe.
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