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Blood tests of thyroid functions including TSH, T4 and T3 are usually normal [3] Ultrasonographic examination often shows the abscess or swelling in thyroid; Gallium scan will be positive; Barium swallow will show fistula connection to the piriform sinus and left lobe; Elevated white blood cell count [3] Elevated erythrocyte sedimentation rate [3]
[3] [10] The diagnosis of hypothyroidism, when suspected, can be confirmed with blood tests measuring thyroid-stimulating hormone (TSH) and thyroxine (T4) levels. [3] Salt iodization has prevented hypothyroidism in many populations. [7] Thyroid hormone replacement with levothyroxine treats hypothyroidism. [3]
[9] [10] The first English-language report, in 1931, originated from Dunlap and Kepler, physicians at the Mayo Clinic; they described the condition in a patient with features of Graves' disease. [ 2 ] [ 10 ] In 1937 periodic paralysis was linked with hypokalemia, as well as precipitation of attacks with glucose and insulin.
[10] [3] IL-1β has been shown to decrease liver D1, [10] as well as thyroid hormone receptor (THR) levels. IL-6 and TNFa downregulate D1 and suppress TSH, are negatively correlated with fT3, and are positively correlated with rT3. [3] NF-κB also inhibits D1, and decreases the expression of Thyroid receptors α and β. [3]
In the US white people are affected more often than black. It is more common in low to middle income groups. Females are more susceptible with a 17.5% rate of prevalence compared to 6% in males. [9] It is the most common cause of hypothyroidism in developed countries. [10] It typically begins between the ages of 30 and 50.
ICD-10 is the 10th revision of the International Classification of Diseases (ICD), a medical classification list by the World Health Organization (WHO). It contains codes for diseases, signs and symptoms, abnormal findings, complaints, social circumstances, and external causes of injury or diseases. [1]
The syndrome can present with variable symptoms, even between members of the same family harboring the same mutation. [1] Typically most or all tissues are resistant to thyroid hormone, so despite raised measures of serum thyroid hormone the individual may appear euthyroid (have no symptoms of over- or underactivity of the thyroid gland).
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