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  2. Insertion (genetics) - Wikipedia

    en.wikipedia.org/wiki/Insertion_(genetics)

    An illustration of an insertion at chromosome level. In genetics, an insertion (also called an insertion mutation) is the addition of one or more nucleotide base pairs into a DNA sequence. This can often happen in microsatellite regions due to the DNA polymerase slipping. Insertions can be anywhere in size from one base pair incorrectly ...

  3. Insert (molecular biology) - Wikipedia

    en.wikipedia.org/wiki/Insert_(molecular_biology)

    In Molecular biology, an insert is a piece of DNA that is inserted into a larger DNA vector by a recombinant DNA technique, such as ligation or recombination. This allows it to be multiplied, selected, further manipulated or expressed in a host organism .

  4. Insertion sequence - Wikipedia

    en.wikipedia.org/wiki/Insertion_sequence

    Insertion element (also known as an IS, an insertion sequence element, or an IS element) is a short DNA sequence that acts as a simple transposable element.Insertion sequences have two major characteristics: they are small relative to other transposable elements (generally around 700 to 2500 bp in length) and only code for proteins implicated in the transposition activity (they are thus ...

  5. DNA - Wikipedia

    en.wikipedia.org/wiki/DNA

    Genomic DNA is tightly and orderly packed in the process called DNA condensation, to fit the small available volumes of the cell. In eukaryotes, DNA is located in the cell nucleus, with small amounts in mitochondria and chloroplasts. In prokaryotes, the DNA is held within an irregularly shaped body in the cytoplasm called the nucleoid. [97]

  6. Genetic engineering techniques - Wikipedia

    en.wikipedia.org/wiki/Genetic_engineering_techniques

    Transformation has a different meaning in relation to animals, indicating progression to a cancerous state, so the process used to insert foreign DNA into animal cells is usually called transfection. [35] There are many ways to directly introduce DNA into animal cells in vitro. Often these cells are stem cells that are used for gene therapy.

  7. Sleeping Beauty transposon system - Wikipedia

    en.wikipedia.org/wiki/Sleeping_Beauty_transposon...

    The Sleeping Beauty transposon system is composed of a Sleeping Beauty (SB) transposase and a transposon that was designed in 1997 to insert specific sequences of DNA into genomes of vertebrate animals. DNA transposons translocate from one DNA site to another in a simple, cut-and-paste manner (Fig. 1).

  8. Gene delivery - Wikipedia

    en.wikipedia.org/wiki/Gene_delivery

    The transferred DNA is piloted to the plant cell nucleus and integrated into the host plants genomic DNA.The plasmid T-DNA is integrated semi-randomly into the genome of the host cell. [ 23 ] By modifying the plasmid to express the gene of interest, researchers can insert their chosen gene stably into the plants genome.

  9. Hydrodynamic delivery - Wikipedia

    en.wikipedia.org/wiki/Hydrodynamic_delivery

    After injection, the majority of genes are expressed in the liver of the animal over a long period of time. [6] [3] Originally developed to insert DNA, further developments in HD have enabled the insertion of RNA, proteins, and short oligonucleotides into cells. [6] The high pressure of the injection forces the pores of the cell membrane to ...

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