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Iron overload (also known as haemochromatosis or hemochromatosis) is the abnormal and increased accumulation of total iron in the body, leading to organ damage. [1] The primary mechanism of organ damage is oxidative stress, as elevated intracellular iron levels increase free radical formation via the Fenton reaction.
Excessive iron can lead to a condition called hemochromatosis, which may damage organs like the liver, heart and pancreas. Symptoms of iron overload include fatigue, skin discoloration, and joint ...
Haemochromatosis is more severe than previously thought and is often diagnosed too late. But the treatment is simple. Haemochromatosis: disorder that causes body to absorb too much iron from food ...
Age. The risk of most causes of joint pain increases with age. This may be due to increased wear and stress on joints over time and a higher likelihood of other underlying medical conditions ...
The aims of iron chelation therapy include (a) prevention therapy in order to minimize the risk of onset of iron-mediated complications, (b) rescue therapy for the removal of storage iron and (c) emergency therapy if heart failure develops or if there is a downward trend of left ventricular (LV) function that requires hospitalisation using ...
Iron is stored in the liver, pancreas and heart. Long-term effects of haemochromatosis on these organs can be serious, even fatal when untreated. [22] Since the liver is a primary storage area for iron and naturally accumulates excess iron over time, it is likely to be damaged by iron overload.
The symptoms of type 4B hemochromatosis tend to be more severe. They resemble the symptoms of hemochromatosis types 1, 2, and 3. Plasma iron concentration is elevated, and symptoms include joint pain, diabetes, and arrhythmia. Liver iron deposition tends to be greater in type 4B than in type 4A. [5]
“Those who are iron deficient likely feel weakness, headaches, fatigue, pale, and/or have joint pain,” says Eric Ascher, DO, a family medicine physician at Lenox Hill Hospital.
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